Skypala Isabel, Vlieg-Boerstra Berber
aRoyal Brompton and Harefield NHS Foundation Trust, London, UK bEmma Children's Hospital, Pediatric Respiratory Medicine and Allergy, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
Curr Opin Clin Nutr Metab Care. 2014 Sep;17(5):442-7. doi: 10.1097/MCO.0000000000000086.
The role of nutrients in the study of allergic disease has been studied for many years, but recent evidence suggests that it is the quality and variety of the whole diet which affects the development of food allergy. This review seeks to understand whether food allergy prevalence is increasing and the role of diet in the development of the disease.
New data on the European and global prevalence of food allergy suggest that both reported and actual rates are increasing. Recent findings from studies in infants and children indicated that a Western diet could enhance the development of allergic disease, possibly due to an effect on the homeostasis of the gut microbiome, impacting the immune status of individuals.
With overall prevalence rates for food allergy increasing, it is important to ascertain the relevance of dietary influences. Attention has shifted from single-nutrient prevention studies to evaluation of the effect of different dietary patterns on allergic outcomes. Evidence suggests that introduction of complementary foods should not be delayed, and the diversity of the diet in early life is important. The increasingly processed nature of the Western diet, in combination with influences on the gut microbiome, may contribute to the rising prevalence of allergic disease, including food allergy.
营养物质在过敏性疾病研究中的作用已被研究多年,但最近的证据表明,影响食物过敏发生发展的是整个饮食的质量和多样性。本综述旨在了解食物过敏的患病率是否正在上升以及饮食在该疾病发生发展中的作用。
关于欧洲和全球食物过敏患病率的新数据表明,报告的患病率和实际患病率都在上升。近期对婴幼儿的研究结果表明,西式饮食可能会促进过敏性疾病的发生发展,这可能是由于其对肠道微生物群稳态的影响,进而影响个体的免疫状态。
随着食物过敏总体患病率的上升,确定饮食影响的相关性很重要。关注重点已从单一营养素预防研究转向评估不同饮食模式对过敏结局的影响。有证据表明,不应延迟引入辅食,生命早期饮食的多样性很重要。西式饮食日益增加的加工特性,再加上对肠道微生物群的影响,可能导致包括食物过敏在内的过敏性疾病患病率上升。