Kim Hye Won, Kim Yang-Hyun, Han Kyungdo, Nam Ga Eun, Kim Gwang Seon, Han Byoung-Duck, Lee Anna, Ahn Ji Yong, Ko Byung Joon
Department of Family Medicine, College of Medicine, Korea University, Seoul, Korea.
Department of Biostatistics, College of Medicine, Catholic University, Seoul, Korea.
PLoS One. 2014 Jul 8;9(7):e101852. doi: 10.1371/journal.pone.0101852. eCollection 2014.
Osteoporosis poses a great threat to the aging society. Hypochlorhydric or achlorhydric conditions are risk factors for osteoporosis. Atrophic gastritis also decreases gastric acid production; however, the role of atrophic gastritis as a related factor for osteoporosis is unclear. We investigated the relationship between atrophic gastritis and osteoporosis in postmenopausal women over 60 years of age.
A total of 401 postmenopausal women were included in this cross-sectional study, which was conducted during their medical check-ups. Bone mineral densitometry was measured using a dual energy X-ray absorptiometry. Atrophic gastritis was defined endoscopically if gastric mucosa in the antrum and the body were found to be atrophied and thinned and submucosal vessels could be well visualized.
The proportion of people with atrophic gastritis was higher in the osteoporotic group than in the group without osteoporosis. A linear relationship was observed in the proportion of atrophic gastritis according to the categories of normal, osteopenia, and osteoporosis at the lumbar spine (p for trend = 0.039) and femur (p for trend = 0.001). A multiple logistic regression analysis revealed that the presence of atrophic gastritis was associated with an increased odds of osteoporosis after adjusting for age, body mass index, triglyceride, high-density lipoprotein cholesterol, alcohol consumption, and smoking status (odds ratio 1.89, 95% confidence interval 1.15-3.11).
Atrophic gastritis is associated with an increased likelihood of osteoporosis in Korean elderly women.
骨质疏松症对老龄化社会构成巨大威胁。胃酸过少或无酸状态是骨质疏松症的危险因素。萎缩性胃炎也会减少胃酸分泌；然而，萎缩性胃炎作为骨质疏松症相关因素的作用尚不清楚。我们调查了60岁以上绝经后女性中萎缩性胃炎与骨质疏松症之间的关系。
本横断面研究共纳入401名绝经后女性，研究在她们进行体检期间进行。使用双能X线吸收法测量骨密度。如果发现胃窦和胃体的胃黏膜萎缩变薄且黏膜下血管清晰可见，则在内镜下定义为萎缩性胃炎。
骨质疏松组中萎缩性胃炎患者的比例高于非骨质疏松组。在腰椎（趋势p值 = 0.039）和股骨（趋势p值 = 0.001）处，根据正常、骨量减少和骨质疏松的类别，观察到萎缩性胃炎比例呈线性关系。多因素logistic回归分析显示，在调整年龄、体重指数、甘油三酯、高密度脂蛋白胆固醇、饮酒和吸烟状况后，萎缩性胃炎的存在与骨质疏松症的患病几率增加相关（比值比1.89，95%置信区间1.15 - 3.11）。
在韩国老年女性中，萎缩性胃炎与骨质疏松症患病可能性增加有关。
