Affiliations of authors: Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC (BSC, BBR); Department of Radiation Oncology, University of Michigan, Ann Arbor, MI (AE); Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN (BAM); Fox Chase Cancer Center, Philadelphia, PA (JAR); Grand Rapids Clinical Oncology Program, Grand Rapids, MI (PG); Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA (DWB); Henry Ford Hospital, Detroit, MI (BM).
J Natl Cancer Inst. 2014 Jul 8;106(7). doi: 10.1093/jnci/dju127. Print 2014 Jul.
We identified a standard core set of patient-reported symptoms and health-related quality-of-life (HRQOL) domains to be assessed in head and neck (H&N) cancer clinical trials. The core symptom and HRQOL domain scores were used to guide recommendations by a working group of experts as part of a National Cancer Institute Symptom Management and HRQOL Clinical Trials Planning Meeting. A PubMed search was conducted using the search terms of "health-related quality of life" and "head & neck cancer," limited to publications from January 1, 2000, to December 31, 2010. Fifty-four articles were used to guide the choice of recommendations. Twenty-nine symptoms and nine domains were identified, from which 12 H&N-specific core symptoms and HRQOL domains were recommended: swallowing, oral pain, skin changes, dry mouth, dental health, opening mouth/trismus, taste, excess/thick mucous/saliva, shoulder disability/motion, voice/hoarseness, social domain, and functional domain. This core set of 12 H&N-specific, patient-reported symptoms and HRQOL domains should be assessed in future H&N cancer clinical trials.
我们确定了一套标准的核心患者报告症状和健康相关生活质量（HRQOL）领域，以便在头颈部（H&N）癌症临床试验中进行评估。核心症状和 HRQOL 领域评分被用作指导专家组建议的依据，这是美国国家癌症研究所症状管理和 HRQOL 临床试验规划会议的一部分。使用“健康相关生活质量”和“头颈部癌症”的搜索词，对 PubMed 进行了搜索，仅限于 2000 年 1 月 1 日至 2010 年 12 月 31 日的出版物。使用了 54 篇文章来指导建议的选择。确定了 29 种症状和 9 个领域，从中推荐了 12 个 H&N 特定的核心症状和 HRQOL 领域：吞咽、口腔疼痛、皮肤变化、口干、口腔健康、张口/牙关紧闭、味觉、过多/浓稠的黏液/唾液、肩部残疾/运动、声音/嘶哑、社会领域和功能领域。未来的 H&N 癌症临床试验中应评估这套 12 个特定于 H&N 的、患者报告的症状和 HRQOL 领域的核心集合。
