Institute of Molecular and Translational Therapeutic Strategies (IMTTS) and Integrated Research and Treatment Center Transplantation (IFB-Tx), Hannover Medical School, Hannover, Germany ; Excellence Cluster REBIRTH, Hannover Medical School, Hannover, Germany; and National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Institute of Molecular and Translational Therapeutic Strategies (IMTTS) and Integrated Research and Treatment Center Transplantation (IFB-Tx), Hannover Medical School, Hannover, Germany.
Pulm Circ. 2014 Jun;4(2):185-90. doi: 10.1086/675981.
MicroRNAs (miRNAs) are molecules increasingly investigated for both diagnostic and therapeutic strategies. Whereas information about their role in the left ventricle has been studied for many years, there is scarce information about the right ventricle. We thus here review known details about the expression, regulation, and function of miRNAs in right heart diseases. Current identified therapeutic strategies using miRNA modulators to treat pulmonary hypertension and thus also having beneficial effects on the right ventricle are also discussed. Finally, the current knowledge about the diagnostic and predictive use of circulating miRNAs in patients with pulmonary hypertension and right ventricular failure is presented. There is strong hope that the increasing knowledge about miRNAs in the right heart will finally help to improve the treatment of patients with pulmonary and right ventricular heart diseases.
微小 RNA（miRNAs）是越来越受到关注的分子，既可以用于诊断策略，也可以用于治疗策略。尽管人们已经研究了它们在左心室中的作用多年，但关于右心室的信息却很少。因此，我们在这里回顾了已知的关于微小 RNA 在右心疾病中的表达、调节和功能的详细信息。目前使用 miRNA 调节剂治疗肺动脉高压的治疗策略也被讨论，因为它们对右心室也有有益的影响。最后，还介绍了目前关于循环微小 RNA 在肺动脉高压和右心衰竭患者中的诊断和预测用途的知识。人们强烈希望对右心微小 RNA 的日益增长的认识最终将有助于改善肺动脉高压和右心疾病患者的治疗。
