需要认识到肺循环和右心室是一个整合的功能单元：事实和假说（2013 年 Grover 会议系列）。
The need to recognize the pulmonary circulation and the right ventricle as an integrated functional unit: facts and hypotheses (2013 Grover Conference series).
机构信息
Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia, USA.
Department of Pulmonary Medicine, Vrije Universiteit (VU) Medical Center, Amsterdam, Netherlands.
出版信息
Pulm Circ. 2015 Mar;5(1):81-9. doi: 10.1086/679702.
Abstract
For many patients with severe pulmonary arterial hypertension, heart failure-and, in particular, right heart failure-is the final chapter of their chronic illness. Targeted therapy for pulmonary hypertension is effective only if the right ventricular ejection fraction is maintained or improved. Because improvement of right heart function and reversal of right heart failure are treatment goals, it is important to investigate the cellular and molecular mechanisms that cause right heart failure. Here, we propose that right ventricular capillary rarefaction is an important hallmark of right heart failure and consider that the "sick lung circulation" and the pressure-overloaded right ventricle constitute a functional unit.
摘要
对于许多患有严重肺动脉高压的患者来说，心力衰竭——尤其是右心衰竭——是他们慢性疾病的最后一章。肺动脉高压的靶向治疗只有在维持或改善右心室射血分数的情况下才有效。由于改善右心功能和逆转右心衰竭是治疗目标，因此研究导致右心衰竭的细胞和分子机制非常重要。在这里，我们提出右心室毛细血管稀疏是右心衰竭的一个重要标志，并认为“病态肺循环”和压力超负荷的右心室构成一个功能单元。
相似文献
1
2
The right ventricle and pulmonary hypertension.右心室与肺动脉高压。
Heart Fail Rev. 2016 May;21(3):259-71. doi: 10.1007/s10741-016-9526-y.
3
The right ventricle under pressure: evaluating the adaptive and maladaptive changes in the right ventricle in pulmonary arterial hypertension using echocardiography (2013 Grover Conference series).受压的右心室：应用超声心动图评估肺动脉高压中右心室的适应性和失代偿性改变（2013 年 Grover 会议系列）。
Pulm Circ. 2015 Mar;5(1):29-47. doi: 10.1086/679699.
4
[Experts consensus on the management of the right heart function in critically ill patients].[危重症患者右心功能管理的专家共识]
Zhonghua Nei Ke Za Zhi. 2017 Dec 1;56(12):962-973. doi: 10.3760/cma.j.issn.0578-1426.2017.12.017.
5
Mechanisms of right heart disease in pulmonary hypertension (2017 Grover Conference Series).肺动脉高压所致右心疾病的机制（2017年格罗弗会议系列）
Pulm Circ. 2018 Jan-Mar;8(1):2045893217753121. doi: 10.1177/2045893217753121. Epub 2017 Dec 21.
6
Stem and progenitor cell therapy for pulmonary arterial hypertension: effects on the right ventricle (2013 Grover Conference Series).肺动脉高压的干细胞和祖细胞治疗：对右心室的影响（2013 年 Grover 会议系列）。
Pulm Circ. 2015 Mar;5(1):73-80. doi: 10.1086/679701.
7
The Right Heart-Pulmonary Circulation Unit in Systemic Hypertension.右心-肺循环单位与系统性高血压。
Heart Fail Clin. 2018 Jul;14(3):247-253. doi: 10.1016/j.hfc.2018.02.002.
8
RV Contractile Function and its Coupling to Pulmonary Circulation in Heart Failure With Preserved Ejection Fraction: Stratification of Clinical Phenotypes and Outcomes.射血分数保留的心力衰竭中 RV 收缩功能及其与肺循环的耦联：临床表型和结局的分层。
JACC Cardiovasc Imaging. 2017 Oct;10(10 Pt B):1211-1221. doi: 10.1016/j.jcmg.2016.12.024. Epub 2017 Apr 12.
9
Value of right ventricular ejection fraction in predicting short-term prognosis of patients with severe chronic heart failure.右心室射血分数对预测重度慢性心力衰竭患者短期预后的价值。
J Heart Lung Transplant. 1997 Jul;16(7):774-85.
10
The Right Heart-Pulmonary Circulation Unit: Physiopathology.右心-肺循环单元：病理生理学。
Heart Fail Clin. 2018 Jul;14(3):237-245. doi: 10.1016/j.hfc.2018.02.001.
引用本文的文献
1
Use of Prostaglandin E1 in the Management of Congenital Diaphragmatic Hernia-A Review.前列腺素E1在先天性膈疝治疗中的应用——综述
Front Pediatr. 2022 Jul 1;10:911588. doi: 10.3389/fped.2022.911588. eCollection 2022.
2
Establishment of adult right ventricle failure in ovine using a graded, animal-specific pulmonary artery constriction model.使用分级的、动物特异性肺动脉缩窄模型建立绵羊成人右心室衰竭模型。
Animal Model Exp Med. 2020 Jun 14;3(2):182-192. doi: 10.1002/ame2.12124. eCollection 2020 Jun.
3
Supra-coronary aortic banding improves right ventricular function in experimental pulmonary arterial hypertension in rats by increasing systolic right coronary artery perfusion.冠状窦上方主动脉缩窄通过增加收缩期右冠状动脉灌注改善大鼠实验性肺动脉高压的右心室功能。
Acta Physiol (Oxf). 2020 Aug;229(4):e13483. doi: 10.1111/apha.13483. Epub 2020 May 17.
4
Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension: A Pyruvate Dehydrogenase Kinase-Dependent Shift in Mitochondrial Metabolism Promotes Right Ventricular Fibrosis.肺动脉高压右心室成纤维细胞的表观遗传代谢重编程：依赖于丙酮酸脱氢酶激酶的线粒体代谢转变促进右心室纤维化。
Circ Res. 2020 Jun 5;126(12):1723-1745. doi: 10.1161/CIRCRESAHA.120.316443. Epub 2020 Mar 27.
5
Fischer rats exhibit maladaptive structural and molecular right ventricular remodelling in severe pulmonary hypertension: a genetically prone model for right heart failure.费希尔大鼠在严重肺动脉高压时表现出适应性不良的结构和分子右心室重构：一种易患右心衰竭的遗传性模型。
Cardiovasc Res. 2019 Mar 15;115(4):788-799. doi: 10.1093/cvr/cvy258.
6
Increased Drp1-Mediated Mitochondrial Fission Promotes Proliferation and Collagen Production by Right Ventricular Fibroblasts in Experimental Pulmonary Arterial Hypertension.Drp1介导的线粒体分裂增加促进实验性肺动脉高压中右心室成纤维细胞的增殖和胶原蛋白生成。
Front Physiol. 2018 Jul 10;9:828. doi: 10.3389/fphys.2018.00828. eCollection 2018.
7
Mesenchymal stromal cell therapy reduces lung inflammation and vascular remodeling and improves hemodynamics in experimental pulmonary arterial hypertension.间质基质细胞疗法可减轻实验性肺动脉高压中的肺部炎症和血管重构，并改善血液动力学。
Stem Cell Res Ther. 2017 Oct 3;8(1):220. doi: 10.1186/s13287-017-0669-0.
8
Therapeutic effect of prostaglandin E1 in monocrotaline-induced pulmonary arterial hypertension rats.前列腺素E1对野百合碱诱导的肺动脉高压大鼠的治疗作用。
Anat Cell Biol. 2017 Mar;50(1):60-68. doi: 10.5115/acb.2017.50.1.60. Epub 2017 Mar 29.
9
Altered mTOR and Beclin-1 mediated autophagic activation during right ventricular remodeling in monocrotaline-induced pulmonary hypertension.在野百合碱诱导的肺动脉高压右心室重塑过程中，mTOR和Beclin-1介导的自噬激活发生改变。
Respir Res. 2017 Mar 24;18(1):53. doi: 10.1186/s12931-017-0536-7.
10
Pulmonary Perfusion and Ventilation during Cardiopulmonary Bypass Are Not Associated with Improved Postoperative Outcomes after Cardiac Surgery.体外循环期间的肺灌注和通气与心脏手术后改善的术后结局无关。
Front Cardiovasc Med. 2016 Nov 28;3:47. doi: 10.3389/fcvm.2016.00047. eCollection 2016.
本文引用的文献
1
Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology.右心对肺动脉高压的适应：生理学和病理生物学。
J Am Coll Cardiol. 2013 Dec 24;62(25 Suppl):D22-33. doi: 10.1016/j.jacc.2013.10.027.
2
Right ventricular diastolic impairment in patients with pulmonary arterial hypertension.肺动脉高压患者的右心室舒张功能障碍。
Circulation. 2013 Oct 29;128(18):2016-25, 1-10. doi: 10.1161/CIRCULATIONAHA.113.001873. Epub 2013 Sep 20.
3
Cardiac aging and rejuvenation--a sense of humors?心脏衰老与年轻化——一种幽默的说法？
N Engl J Med. 2013 Aug 8;369(6):575-6. doi: 10.1056/NEJMcibr1306063.
4
FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension.FK506 激活 BMPR2，挽救内皮功能障碍，逆转肺动脉高压。
J Clin Invest. 2013 Aug;123(8):3600-13. doi: 10.1172/JCI65592. Epub 2013 Jul 15.
5
A metabolic remodeling in right ventricular hypertrophy is associated with decreased angiogenesis and a transition from a compensated to a decompensated state in pulmonary hypertension.右心室肥厚中的代谢重塑与血管生成减少以及肺动脉高压从代偿状态向失代偿状态的转变有关。
J Mol Med (Berl). 2013 Nov;91(11):1315-27. doi: 10.1007/s00109-013-1059-4. Epub 2013 Jul 12.
6
Dehydroepiandrosterone restores right ventricular structure and function in rats with severe pulmonary arterial hypertension.脱氢表雄酮可恢复肺动脉高压大鼠的右心室结构和功能。
Am J Physiol Heart Circ Physiol. 2013 Jun 15;304(12):H1708-18. doi: 10.1152/ajpheart.00746.2012. Epub 2013 Apr 12.
7
Autophagy in human health and disease.自噬与人类健康和疾病
N Engl J Med. 2013 Feb 14;368(7):651-62. doi: 10.1056/NEJMra1205406.
8
Proteotoxicity and cardiac dysfunction--Alzheimer's disease of the heart?蛋白毒性与心脏功能障碍——心脏的阿尔茨海默病？
N Engl J Med. 2013 Jan 31;368(5):455-64. doi: 10.1056/NEJMra1106180.
9
Describing right ventricular function.描述右心室功能。
Eur Respir J. 2013 Jun;41(6):1419-23. doi: 10.1183/09031936.00160712. Epub 2013 Jan 11.
10
Endothelin axis is upregulated in human and rat right ventricular hypertrophy.内皮素轴在人和大鼠右心室肥厚中上调。
Circ Res. 2013 Jan 18;112(2):347-54. doi: 10.1161/CIRCRESAHA.111.300448. Epub 2012 Dec 10.
Zotero 插件