Pulkkinen M O
Department of Obstetrics and Gynecology, University of Turku, Finland.
Prostaglandins Leukot Essent Fatty Acids. 1989 Apr;36(1):15-9. doi: 10.1016/0952-3278(89)90156-7.
In acute experiments eleven nonpregnant women received a single oral dose of enprostil (prostaglandin E2 analogue) 35-140 mcg. Uterine activity was measured by a microtransducer-tipped Millar catheter. A single, oral dose of enprostil caused a long-lasting contracture response of the uterus. 3 h after enprostil, uterine resting pressure (RP) was still high. In chronic experiments, eleven women with regular menstrual cycles received 35 mcg or 70 mcg BID enprostil and placebo in a crossover, double-blind fashion from cycle day 10 +/- 3 for four weeks, then had a washout period of four weeks followed by another four-week treatment period. An increase of uterine RP after enprostil was dose-dependent. After two weeks of twice-daily administration of enprostil, the baseline RP was lower than after placebo (p less than 0.01) and the increase in RP after the morning enprostil less than that seen on the first day. In eight patients studied, the mean values of plasma progesterone were normal, both during placebo--and enprostil--treated cycles.
在急性实验中，11名未怀孕女性单次口服35 - 140微克恩前列素（前列腺素E2类似物）。子宫活动通过带有微型传感器的米拉尔导管进行测量。单次口服恩前列素会引起子宫持久的挛缩反应。服用恩前列素3小时后，子宫静息压力（RP）仍处于高位。在慢性实验中，11名月经周期规律的女性从月经周期第10±3天开始，以交叉、双盲方式接受35微克或70微克每日两次的恩前列素及安慰剂治疗，为期四周，然后有四周的洗脱期，随后是另一个四周的治疗期。恩前列素治疗后子宫RP的升高呈剂量依赖性。每日两次服用恩前列素两周后，基线RP低于服用安慰剂后（p < 0.01），且早晨服用恩前列素后RP的升高幅度小于第一天。在8名接受研究的患者中，在服用安慰剂和恩前列素治疗的周期中，血浆孕酮的平均值均正常。
