人类胃癌的代谢组学研究：综述
Metabolomic studies of human gastric cancer: review.
作者信息
Jayavelu Naresh Doni, Bar Nadav S
机构信息
Naresh Doni Jayavelu, Nadav S Bar, Department of Chemical Engineering, Norwegian University of Science and Technology, N7491 Trondheim, Norway.
出版信息
World J Gastroenterol. 2014 Jul 7;20(25):8092-101. doi: 10.3748/wjg.v20.i25.8092.
Abstract
Metabolomics is a field of study in systems biology that involves the identification and quantification of metabolites present in a biological system. Analyzing metabolic differences between unperturbed and perturbed networks, such as cancerous and non-cancerous samples, can provide insight into underlying disease pathology, disease prognosis and diagnosis. Despite the large number of review articles concerning metabolomics and its application in cancer research, biomarker and drug discovery, these reviews do not focus on a specific type of cancer. Metabolomics may provide biomarkers useful for identification of early stage gastric cancer, potentially addressing an important clinical need. Here, we present a short review on metabolomics as a tool for biomarker discovery in human gastric cancer, with a primary focus on its use as a predictor of anticancer drug chemosensitivity, diagnosis, prognosis, and metastasis.
摘要
代谢组学是系统生物学中的一个研究领域，涉及对生物系统中存在的代谢物进行鉴定和定量。分析未受干扰和受干扰网络（如癌性和非癌性样本）之间的代谢差异，可以深入了解潜在的疾病病理、疾病预后和诊断。尽管有大量关于代谢组学及其在癌症研究、生物标志物和药物发现中的应用的综述文章，但这些综述并未聚焦于特定类型的癌症。代谢组学可能提供有助于早期胃癌识别的生物标志物，从而潜在地满足一项重要的临床需求。在此，我们对代谢组学作为人类胃癌生物标志物发现工具进行简要综述，主要关注其作为抗癌药物化学敏感性、诊断、预后和转移预测指标的用途。
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本文引用的文献
1
Lymph node metastasis of gastric cancer.胃癌淋巴结转移。
Cancers (Basel). 2011 Apr 26;3(2):2141-59. doi: 10.3390/cancers3022141.
2
Serum metabolic profiling of human gastric cancer based on gas chromatography/mass spectrometry.基于气相色谱/质谱联用的人胃癌血清代谢组学分析。
Braz J Med Biol Res. 2012 Jan;45(1):78-85. doi: 10.1590/s0100-879x2011007500158. Epub 2011 Nov 25.
3
Global proteomics and metabolomics in cancer biomarker discovery.癌症生物标志物发现中的全球蛋白质组学和代谢组学。
J Sep Sci. 2011 Dec;34(24):3484-92. doi: 10.1002/jssc.201100528. Epub 2011 Nov 21.
4
Diversity of human leukemia xenograft mouse models: implications for disease biology.人类白血病异种移植小鼠模型的多样性：对疾病生物学的影响。
Cancer Res. 2011 Dec 1;71(23):7141-4. doi: 10.1158/0008-5472.CAN-11-1732. Epub 2011 Nov 16.
5
A novel patient-derived intra-femoral xenograft model of bone metastatic prostate cancer that recapitulates mixed osteolytic and osteoblastic lesions.一种新型的源自患者的股骨内异种移植物骨转移前列腺癌模型，可重现混合溶骨性和成骨性病变。
J Transl Med. 2011 Oct 28;9:185. doi: 10.1186/1479-5876-9-185.
6
Bioinformatics tools for cancer metabolomics.用于癌症代谢组学的生物信息学工具
Metabolomics. 2011 Sep;7(3):329-343. doi: 10.1007/s11306-010-0270-3. Epub 2011 Jan 12.
7
Recombinant human endostatin endostar inhibits tumor growth and metastasis in a mouse xenograft model of colon cancer.重组人血管内皮抑制素恩度抑制结肠癌裸鼠移植瘤模型的生长和转移。
Pathol Oncol Res. 2012 Apr;18(2):315-23. doi: 10.1007/s12253-011-9447-y. Epub 2011 Sep 22.
8
Antitumor activities of recombinant human interferon (IFN)-λ1 in vitro and in xenograft models in vivo for colon cancer.重组人干扰素（IFN）-λ1 在体外和体内异种移植模型中对结肠癌的抗肿瘤活性。
Cancer Lett. 2011 Dec 8;311(2):141-51. doi: 10.1016/j.canlet.2011.07.004. Epub 2011 Jul 14.
9
Comparing the efficacy of sunitinib with sorafenib in xenograft models of human hepatocellular carcinoma: mechanistic explanation.比较舒尼替尼与索拉非尼在人肝癌异种移植模型中的疗效：机制解释。
Curr Cancer Drug Targets. 2011 Oct;11(8):944-53. doi: 10.2174/156800911797264716.
10
[Effect of sodium cantharidinate on the angiogenesis of nude mice with human gastric cancer].斑蝥酸钠对人胃癌裸鼠血管生成的影响
Zhong Yao Cai. 2011 Mar;34(3):343-6.
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