Department of Biomaterials and Biomimetics and Periodontology and Implant Dentistry, New York University College of Dentistry, New York, USA; Division of Engineering, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates.
Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden.
Arch Biochem Biophys. 2014 Nov 1;561:99-108. doi: 10.1016/j.abb.2014.06.033. Epub 2014 Jul 8.
Osseointegration of metallic devices has been one of the most successful treatments in rehabilitative dentistry and medicine over the past five decades. While highly successful, the quest for designing surgical instrumentation and associated implantable devices that hastens osseointegration has been perpetual and has often been approached as single variable preclinical investigations. The present manuscript presents how the interplay between surgical instrumentation and device macrogeometry not only plays a key role on both early and delayed stages of osseointegration, but may also be key in how efficient smaller length scale designing (at the micrometer and nanometer scale levels) may be in hastening early stages of osseointegration.
在过去的五十年中，金属设备的骨整合已成为修复牙科和医学中最成功的治疗方法之一。虽然非常成功，但设计加速骨整合的手术器械和相关植入设备的追求是永恒的，并且通常被视为单一变量的临床前研究。本文介绍了手术器械和器械宏观几何形状之间的相互作用不仅在骨整合的早期和晚期阶段起着关键作用，而且在如何有效地进行更小长度尺度设计（在微米和纳米尺度水平）以加速骨整合的早期阶段方面也可能是关键。
