Gillis Annika, Mahillon Jacques
Laboratory of Food and Environmental Microbiology, Université catholique de Louvain, Croix du Sud 2, L7.05.12, B-1348 Louvain-la-Neuve, Belgium.
Viruses. 2014 Jul 9;6(7):2623-72. doi: 10.3390/v6072623.
Many bacteriophages (phages) have been widely studied due to their major role in virulence evolution of bacterial pathogens. However, less attention has been paid to phages preying on bacteria from the Bacillus cereus group and their contribution to the bacterial genetic pool has been disregarded. Therefore, this review brings together the main information for the B. cereus group phages, from their discovery to their modern biotechnological applications. A special focus is given to phages infecting Bacillus anthracis, B. cereus and Bacillus thuringiensis. These phages belong to the Myoviridae, Siphoviridae, Podoviridae and Tectiviridae families. For the sake of clarity, several phage categories have been made according to significant characteristics such as lifestyles and lysogenic states. The main categories comprise the transducing phages, phages with a chromosomal or plasmidial prophage state, γ-like phages and jumbo-phages. The current genomic characterization of some of these phages is also addressed throughout this work and some promising applications are discussed here.
许多噬菌体因其在细菌病原体毒力进化中的主要作用而受到广泛研究。然而，对捕食蜡样芽孢杆菌群细菌的噬菌体关注较少，它们对细菌基因库的贡献也被忽视了。因此，本综述汇集了蜡样芽孢杆菌群噬菌体的主要信息，从它们的发现到现代生物技术应用。特别关注感染炭疽芽孢杆菌、蜡样芽孢杆菌和苏云金芽孢杆菌的噬菌体。这些噬菌体属于肌尾噬菌体科、长尾噬菌体科、短尾噬菌体科和覆盖噬菌体科。为了清晰起见，根据生活方式和溶原状态等显著特征划分了几个噬菌体类别。主要类别包括转导噬菌体、具有染色体或质粒原噬菌体状态的噬菌体、γ样噬菌体和巨型噬菌体。本文还介绍了其中一些噬菌体目前的基因组特征，并讨论了一些有前景的应用。
