• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Enhancement of growth of Mycobacterium lepraemurium in macrophages by gamma interferon.γ干扰素增强鼠麻风分枝杆菌在巨噬细胞中的生长
Infect Immun. 1989 Aug;57(8):2586-7. doi: 10.1128/iai.57.8.2586-2587.1989.
2
Modulation of Mycobacterium lepraemurium growth in murine macrophages: beneficial effect of tumor necrosis factor alpha and granulocyte-macrophage colony-stimulating factor.鼠巨噬细胞中鼠麻风分枝杆菌生长的调节：肿瘤坏死因子α和粒细胞巨噬细胞集落刺激因子的有益作用
Infect Immun. 1991 Feb;59(2):705-7. doi: 10.1128/iai.59.2.705-707.1991.
3
Cytokine modulation of Mycobacterium lepraemurium infection in mice; important involvement of tumor necrosis factor, interleukin-2 and dissociation from macrophage activation.细胞因子对小鼠感染鼠麻风杆菌的调节作用；肿瘤坏死因子、白细胞介素-2的重要参与以及与巨噬细胞激活的解离
Int J Immunopharmacol. 1991;13(7):889-95. doi: 10.1016/0192-0561(91)90041-5.
4
Strain differences in mouse cellular responses to Mycobacterium lepraemurium and BCG subcutaneous infections. II. Production of interleukins 2, 4, and 6 and of interferon-gamma by draining lymph node cells.小鼠对鼠麻风杆菌和卡介苗皮下感染的细胞反应中的品系差异。II. 引流淋巴结细胞产生白细胞介素2、4和6以及γ干扰素。
Clin Immunol Immunopathol. 1991 Sep;60(3):443-54. doi: 10.1016/0090-1229(91)90100-o.
5
Mycobacterium lepraemurium activates macrophages but fails to trigger release of superoxide anion.鼠麻风分枝杆菌可激活巨噬细胞，但无法触发超氧阴离子的释放。
J Immunol. 1988 Jun 1;140(11):3956-61.
6
Activated murine natural killer cells control growth of Mycobacterium lepraemurium in mouse macrophages; in vitro and in vivo evidence.
Int J Immunopharmacol. 1991;13(7):881-7. doi: 10.1016/0192-0561(91)90040-e.
7
Growth of Mycobacterium lepraemurium in cultures of macrophages obtained from various sources.来自不同来源的巨噬细胞培养物中鼠麻风分枝杆菌的生长情况。
Infect Immun. 1977 Sep;17(3):531-4. doi: 10.1128/iai.17.3.531-534.1977.
8
Macrophages and protective immunity in Mycobacterium lepraemurium infections in a 'resistant' (C57Bl) and a 'susceptible' (BALB/c) mouse strain.在“抗性”（C57Bl）和“易感”（BALB/c）小鼠品系中，巨噬细胞与鼠麻风分枝杆菌感染中的保护性免疫
Clin Exp Immunol. 1982 Feb;47(2):243-52.
9
Growth of Mycobacterium lepraemurium in nonstimulated and stimulated mouse peritoneal-derived and bone marrrow-derived macrophages in vitro.鼠麻风杆菌在体外未刺激及刺激的小鼠腹腔来源和骨髓来源巨噬细胞中的生长情况。
Infect Immun. 1978 Dec;22(3):631-6. doi: 10.1128/iai.22.3.631-636.1978.
10
Recombinant interleukin-2 limits the replication of Mycobacterium lepraemurium and Mycobacterium bovis BCG in mice.重组白细胞介素-2可限制鼠麻风杆菌和牛分枝杆菌卡介苗在小鼠体内的复制。
Infect Immun. 1988 Mar;56(3):660-4. doi: 10.1128/iai.56.3.660-664.1988.

引用本文的文献

1
Differential potentiation of anti-mycobacterial activity and reactive nitrogen intermediate-producing ability of murine peritoneal macrophages activated by interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha).γ干扰素（IFN-γ）和肿瘤坏死因子-α（TNF-α）激活的小鼠腹腔巨噬细胞的抗分枝杆菌活性及产生反应性氮中间产物能力的差异增强作用
Clin Exp Immunol. 1998 Apr;112(1):63-8. doi: 10.1046/j.1365-2249.1998.00554.x.
2
Susceptibility of a panel of virulent strains of Mycobacterium tuberculosis to reactive nitrogen intermediates.一组结核分枝杆菌强毒株对活性氮中间体的敏感性。
Infect Immun. 1997 Apr;65(4):1189-95. doi: 10.1128/iai.65.4.1189-1195.1997.
3
Resistance to nitric oxide in Mycobacterium avium complex and its implication in pathogenesis.鸟分枝杆菌复合群对一氧化氮的抗性及其在发病机制中的意义。
Infect Immun. 1993 May;61(5):1980-9. doi: 10.1128/iai.61.5.1980-1989.1993.
4
Recombinant tumour necrosis factor-alpha decreases whereas recombinant interleukin-6 increases growth of a virulent strain of Mycobacterium avium in human macrophages.重组肿瘤坏死因子-α可降低而重组白细胞介素-6可增加人巨噬细胞中鸟分枝杆菌强毒株的生长。
Immunology. 1990 Sep;71(1):139-41.
5
Killing of Mycobacterium tuberculosis within human monocytes: activation by cytokines and calcitriol.人单核细胞内结核分枝杆菌的杀伤：细胞因子和骨化三醇的激活作用
Clin Exp Immunol. 1991 May;84(2):200-6. doi: 10.1111/j.1365-2249.1991.tb08149.x.
6
Modulation of Mycobacterium avium growth in vivo by cytokines: involvement of tumour necrosis factor in resistance to atypical mycobacteria.细胞因子对体内鸟分枝杆菌生长的调节：肿瘤坏死因子在抗非典型分枝杆菌中的作用。
Clin Exp Immunol. 1991 Mar;83(3):466-71. doi: 10.1111/j.1365-2249.1991.tb05662.x.
7
Modulation of Mycobacterium lepraemurium growth in murine macrophages: beneficial effect of tumor necrosis factor alpha and granulocyte-macrophage colony-stimulating factor.鼠巨噬细胞中鼠麻风分枝杆菌生长的调节：肿瘤坏死因子α和粒细胞巨噬细胞集落刺激因子的有益作用
Infect Immun. 1991 Feb;59(2):705-7. doi: 10.1128/iai.59.2.705-707.1991.

本文引用的文献

1
Killing of Mycobacterium microti by immunologically activated macrophages.免疫激活的巨噬细胞对微小分枝杆菌的杀伤作用。
Nature. 1981 Sep 3;293(5827):69-71. doi: 10.1038/293069a0.
2
Immune responses in mice with murine leprosy.患有鼠麻风病的小鼠的免疫反应。
Clin Exp Immunol. 1970 Jan;6(1):117-24.
3
Gamma interferon activates human macrophages to become tumoricidal and leishmanicidal but enhances replication of macrophage-associated mycobacteria.γ干扰素可激活人类巨噬细胞，使其具有杀肿瘤细胞和杀利什曼原虫的能力，但会增强巨噬细胞相关分枝杆菌的复制。
Infect Immun. 1985 Oct;50(1):1-8. doi: 10.1128/iai.50.1.1-8.1985.
4
Discrepancy in assessment of phagosome-lysosome fusion with two lysosomal markers in murine macrophages infected with Candida albicans.在感染白色念珠菌的小鼠巨噬细胞中，使用两种溶酶体标记物评估吞噬体-溶酶体融合时的差异。
Infect Immun. 1987 Jul;55(7):1663-7. doi: 10.1128/iai.55.7.1663-1667.1987.
5
Regulation of activated macrophage antimicrobial activities. Identification of lymphokines that cooperate with IFN-gamma for induction of resistance to infection.活化巨噬细胞抗菌活性的调节。鉴定与γ干扰素协同诱导抗感染能力的淋巴因子。
J Immunol. 1988 Aug 1;141(3):890-6.
6
Interferon-gamma, the activated macrophage, and host defense against microbial challenge.干扰素-γ、活化巨噬细胞与宿主抵御微生物攻击
Ann Intern Med. 1988 Apr;108(4):595-608. doi: 10.7326/0003-4819-108-4-595.
7
Activation of macrophages to inhibit proliferation of Mycobacterium tuberculosis: comparison of the effects of recombinant gamma-interferon on human monocytes and murine peritoneal macrophages.激活巨噬细胞以抑制结核分枝杆菌的增殖：重组γ干扰素对人单核细胞和小鼠腹腔巨噬细胞作用的比较
Immunology. 1986 Nov;59(3):333-8.
8
Cytokine regulation of the intracellular growth of Mycobacterium paratuberculosis in bovine monocytes.细胞因子对牛单核细胞中副结核分枝杆菌细胞内生长的调节作用
Infect Immun. 1988 Jul;56(7):1692-7. doi: 10.1128/iai.56.7.1692-1697.1988.
9
Attempts to characterize the mechanisms involved in mycobacterial growth inhibition by gamma-interferon-activated bone marrow macrophages.对γ-干扰素激活的骨髓巨噬细胞抑制分枝杆菌生长所涉及机制的研究尝试。
Infect Immun. 1988 Jun;56(6):1464-9. doi: 10.1128/iai.56.6.1464-1469.1988.
10
Growth of Mycobacterium lepraemurium in nonstimulated and stimulated mouse peritoneal-derived and bone marrrow-derived macrophages in vitro.鼠麻风杆菌在体外未刺激及刺激的小鼠腹腔来源和骨髓来源巨噬细胞中的生长情况。
Infect Immun. 1978 Dec;22(3):631-6. doi: 10.1128/iai.22.3.631-636.1978.

γ干扰素增强鼠麻风分枝杆菌在巨噬细胞中的生长

Enhancement of growth of Mycobacterium lepraemurium in macrophages by gamma interferon.

作者信息

Mor N, Goren M B, Crowle A J

机构信息

Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206.

出版信息

Infect Immun. 1989 Aug;57(8):2586-7. doi: 10.1128/iai.57.8.2586-2587.1989.

DOI:10.1128/iai.57.8.2586-2587.1989
PMID:2501220
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC313493/
Abstract

Gamma interferon, an immune lymphokine that protects mouse macrophages against infection by several parasites, was ineffective against Mycobacterium lepraemurium. On the contrary, it significantly stimulated multiplication of M. lepraemurium in the macrophages. Simultaneous treatment of macrophages with gamma interferon and interleukin-4 or interleukin-2 or a combination of all three did not enhance the macrophage resistance to infection with M. lepraemurium, but instead stimulated growth of M. lepraemurium.

摘要

γ干扰素是一种免疫淋巴因子，可保护小鼠巨噬细胞免受多种寄生虫感染，但对鼠麻风杆菌无效。相反，它能显著刺激鼠麻风杆菌在巨噬细胞中的增殖。用γ干扰素与白细胞介素-4或白细胞介素-2或这三种物质的组合同时处理巨噬细胞，并未增强巨噬细胞对鼠麻风杆菌感染的抵抗力，反而刺激了鼠麻风杆菌的生长。