鼠麻风杆菌在体外未刺激及刺激的小鼠腹腔来源和骨髓来源巨噬细胞中的生长情况。
Growth of Mycobacterium lepraemurium in nonstimulated and stimulated mouse peritoneal-derived and bone marrrow-derived macrophages in vitro.
作者信息
Alexander J, Smith C C
出版信息
Infect Immun. 1978 Dec;22(3):631-6. doi: 10.1128/iai.22.3.631-636.1978.
Abstract
Mycobacterium lepraemurium cells were found to multiply in normal mouse peritoneal-derived and bone marrow-derived macrophages in vitro. Whereas activated peritoneal-derived macrophages demonstrated marked bacteriostasis for M. lepraemurium, significant bactericidal activity was exhibited by activated bone marrow-derived macrophages. However, only a small proportion of the bacterial were killed by activated bone marrow-derived macrophages with subsequent and enhanced bacteria growth. It is suggested that a rapid turnover of monocytes in active lesions is required to control mycobacterial infections in vivo. These results would suggest that careful consideration be given to the choice of the host cell in studies involving obligate intracellular parasites.
摘要
在体外发现鼠麻风分枝杆菌细胞可在正常小鼠腹腔来源和骨髓来源的巨噬细胞中增殖。活化的腹腔来源巨噬细胞对鼠麻风分枝杆菌表现出显著的抑菌作用，而活化的骨髓来源巨噬细胞则表现出显著的杀菌活性。然而，活化的骨髓来源巨噬细胞仅杀死了一小部分细菌，随后细菌生长增强。这表明在体内控制分枝杆菌感染需要活动性病变中单核细胞的快速更新。这些结果表明，在涉及专性细胞内寄生虫的研究中，应仔细考虑宿主细胞的选择。
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