Song Yang, Gu Zhuqin, An Jing, Chan Piu
Department of Neurology and Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 10053, China.
Neurol Sci. 2014 Dec;35(12):1991-6. doi: 10.1007/s10072-014-1879-1. Epub 2014 Jul 11.
The affect of gender differences on clinical presentation of Parkinson's disease (PD) remains controversial. De novo PD subjects were recruited from a trial-based multicenter cohort in clinical sites of Chinese Parkinson Study Group. Demographic information, motor and non-motor symptom measurements were performed by face-to-face interview using specific scales. Scores and frequencies of symptoms were compared between male and female patients, and regression models were used to control the effects of age and disease duration. Totally 428 PD patients were enrolled in this study, and 60.3 % of them were male. Total UPDRS scores were not significantly different between male and female (25.02 ± 12.84 vs. 25.24 ± 13.22, adjusted p = 0.984). No significant gender differences were found on scores for four cardinal motor signs, neither on motor subtypes (PIGD 19.0 vs. 15.9 %, adjusted p = 0.303). Female patients more likely had depressive symptoms (38.8 vs. 27.5 %, adjusted p = 0.023; CES-D score 13.78 ± 10.91 vs. 11.23 ± 9.42, adjusted p = 0.015). Male patients had significantly higher scores for MMSE (28.26 ± 2.21 vs. 27.00 ± 3.38, adjusted p = 0.0001), and lower scores for identification (1.39 ± 1.63 vs. 2.01 ± 2.63, adjusted p = 0.002) in ADAS-cog. No significant differences were found for other non-motor symptoms including motivation problems (male 29.8 % vs. female 30.6 %, adjusted p = 0.760), fatigue (62.6 vs. 70.5 %, adjusted p = 0.140), constipation (37.2 vs. 30.1 %, adjusted p = 0.243), and sleep quality (57.6 vs. 61.3 %, adjusted p = 0.357; PSQI score: 5.62 ± 3.31 vs. 6.10 ± 3.53, adjusted p = 0.133). Female might be more depressed and have worse performance on cognition in early untreated PD patients, but gender differences are not apparent on motor and other non-motor symptoms.
性别差异对帕金森病（PD）临床表现的影响仍存在争议。新发PD患者来自中国帕金森研究组临床站点基于试验的多中心队列。通过使用特定量表进行面对面访谈来收集人口统计学信息、运动和非运动症状测量数据。比较男性和女性患者的症状评分及频率，并使用回归模型控制年龄和病程的影响。本研究共纳入428例PD患者，其中60.3%为男性。男性和女性的统一帕金森病评定量表（UPDRS）总分无显著差异（25.02±12.84对25.24±13.22，校正p = 0.984）。在四项主要运动体征评分上未发现显著性别差异，在运动亚型方面也未发现显著差异（姿势不稳-步态障碍型[PIGD]19.0%对15.9%，校正p = 0.303）。女性患者更易出现抑郁症状（38.8%对27.5%，校正p = 0.023；流调中心抑郁量表[CES-D]评分13.78±10.91对11.23±9.42，校正p = 0.015）。男性患者在简易精神状态检查表（MMSE）中的得分显著更高（28.26±2.21对27.00±3.38，校正p = 0.0001），而在阿尔茨海默病协作研究认知量表（ADAS-cog）中的识别得分更低（1.39±1.63对2.01±2.63，校正p = 0.002）。在包括动机问题（男性29.8%对女性30.6%，校正p = 0.760）、疲劳（62.6%对70.5%，校正p = 0.140）、便秘（37.2%对30.1%，校正p = 0.243）及睡眠质量（57.6%对61.3%，校正p = 0.357；匹兹堡睡眠质量指数[PSQI]评分：5.62±3.31对6.10±3.53，校正p = 0.133）等其他非运动症状方面未发现显著差异。在未经治疗的早期PD患者中，女性可能更易抑郁且认知表现更差，但在运动和其他非运动症状上性别差异不明显。
