Xu Jinsheng, Zhang Junxia, Cui Liwen, Zhang Huiran, Zhang Shenglei, Bai Yaling
Department of Nephrology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China.
Oncol Lett. 2014 Aug;8(2):687-692. doi: 10.3892/ol.2014.2196. Epub 2014 May 28.
The receptor tyrosine kinase, ephrin type-A receptor 2 (EphA2), is normally expressed at sites of cell-to-cell contact in adult epithelial tissues, however, recent studies have shown that it is also overexpressed in various types of epithelial carcinomas, with the greatest level of EphA2 expression observed in metastatic lesions. In the present study, the association between the expression of EphA2 and the outcome of RCC patients was assessed. The high expression level of EphA2 was identified by log-rank test for a statistically significant prediction of the RCC outcome. In an overall multivariate analysis, the high expression level of EphA2 was identified as an independent predictor of RCC outcome. The length of survival of the patients with high EphA2 expression was shorter than that of the patients with a low level of expression (relative risk, 2.304; 95% CI, 1.102-4.818; P=0.027). The analysis of the expression levels of EphA2 in tumor tissues may aid in the identification of the patient subgroup that are at a high risk of a poor disease outcome.
受体酪氨酸激酶，埃菲素A 型受体2（EphA2），通常在成人上皮组织的细胞间接触部位表达，然而，最近的研究表明，它在各种类型的上皮癌中也过度表达，在转移灶中观察到EphA2的表达水平最高。在本研究中，评估了EphA2的表达与肾细胞癌（RCC）患者预后之间的关联。通过对数秩检验确定EphA2的高表达水平对RCC预后具有统计学意义的显著预测作用。在总体多变量分析中，EphA2的高表达水平被确定为RCC预后的独立预测因素。EphA2高表达患者的生存时间短于低表达患者（相对风险，2.304；95%可信区间，1.102 - 4.818；P = 0.027）。分析肿瘤组织中EphA2的表达水平可能有助于识别疾病预后不良风险高的患者亚组。
