Kardos T B, Holt T, Ferguson M M
Department of Oral Biology and Oral Pathology, Oral Surgery, School of Dentistry, University of Otago, Dunedin, New Zealand.
Int J Oral Maxillofac Surg. 1989 Apr;18(2):117-20. doi: 10.1016/s0901-5027(89)80145-6.
Carbon dioxide lasers emit infra-red radiation at a wavelength of 10600 nm, making them suitable for tissue vaporisation, incision and vessel coagulation. A miniature CO2 laser (length 24 cm), with an output of 4 Watts focused on to a spot of 0.2 mm diameter at a distance of 2.5 mm from the nozzle tip, has been developed. This hand-held, water-cooled device operates off a 12 V D.C. source and provides good access to most areas of the mouth. In order to evaluate the use of the miniature laser, a series of lesions were produced on the lateral margins of sheep's tongues, and histological examination of tissues carried out immediately after treatment and at 1 h; 1, 2, 4, 7, 14, 21, and 28 day intervals. Wounds showed clean cut margins with even removal of epithelium and superficial connective tissue. Damage appeared to be restricted to a 100 microns deep zone in the lamina propria. Epithelial regeneration had commenced at between 2 and 4 days, and re-covered the surface by 14 days. A residue of chronic inflammatory cells was present within the stroma at 21 days, but this had resolved by 28 days. The miniature carbon dioxide laser is effective in vaporising oral mucosa and also achieving haemostasis by vessel coagulation; its manoeuvrability and relatively low cost warrant further clinical evaluation for the treatment of mucosal lesions, such as leukoplakia.
二氧化碳激光发射波长为10600纳米的红外辐射，使其适用于组织汽化、切割和血管凝固。一种微型二氧化碳激光（长度24厘米）已被研发出来，其输出功率为4瓦，在距喷嘴尖端2.5毫米处聚焦到直径为0.2毫米的光斑上。这种手持式、水冷式设备由12伏直流电源供电，能很好地触及口腔的大部分区域。为了评估微型激光的用途，在羊舌的外侧边缘制造了一系列损伤，并在治疗后立即以及在1小时；1、2、4、7、14、21和28天的间隔时间对组织进行组织学检查。伤口边缘整齐，上皮和浅表结缔组织被均匀去除。损伤似乎局限于固有层中100微米深的区域。上皮再生在2至4天开始，并在14天内覆盖表面。21天时基质中存在慢性炎症细胞残留，但在28天时已消退。微型二氧化碳激光在汽化口腔黏膜以及通过血管凝固实现止血方面是有效的；其可操作性和相对较低的成本值得对黏膜病变（如白斑）的治疗进行进一步的临床评估。
