Yildiz Ali, Beste Christian
Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden, Schubertstrasse 42, 01309, Dresden, Germany.
Department of Biopsychology, Institute for Cognitive Neuroscience, Ruhr-Universität Bochum, Bochum, Germany.
Brain Struct Funct. 2015 Nov;220(6):3131-42. doi: 10.1007/s00429-014-0847-0. Epub 2014 Jul 14.
The lateral prefrontal cortex and the basal ganglia are known to be important for response selection processes, also in dual-task situations. However, response selection in dual-task situations can be achieved using different modes ranging from a parallel selection to a more serial selection of responses. Nothing is known whether differences in these processing modes during dual-tasking have distinct functional neuroanatomical correlates. In this fMRI study we analyzed performance in a psychological refractory period paradigm. In this paradigm we design a PRP task where we vary the frequency of short and long stimulus onset asynchronies between the two tasks. Using mathematical constraints we interpret the effects of this manipulation with respect to processing modes ranging from more serial to more parallel response selection. Contrastingly these blocks showed that response selection in dual-tasking under the constraint of more parallel processing is mediated by mechanisms operating at the striatal level, while response selection under the constraint of more serial processing is mediated via mechanisms operating in the lateral prefrontal cortex. The results suggest that lateral prefrontal and striatal regions are 'optimized' for a certain processing modes in dual tasking.
已知外侧前额叶皮层和基底神经节对于反应选择过程很重要，在双任务情境中也是如此。然而，双任务情境中的反应选择可以通过从并行选择到更串行的反应选择等不同模式来实现。对于双任务期间这些处理模式的差异是否具有独特的功能性神经解剖学相关性，目前尚不清楚。在这项功能磁共振成像（fMRI）研究中，我们分析了心理不应期范式中的表现。在这个范式中，我们设计了一个PRP任务，在两个任务之间改变短和长刺激起始异步的频率。利用数学约束，我们解释了这种操作对于从更串行到更并行反应选择的处理模式的影响。相反，这些组块表明，在更并行处理的约束下，双任务中的反应选择是由纹状体水平上运作的机制介导的，而在更串行处理的约束下进行的反应选择是通过外侧前额叶皮层中运作的机制介导的。结果表明，外侧前额叶和纹状体区域在双任务中针对特定的处理模式进行了“优化”。
