Santos Sérgio Henrique Sousa, Andrade João Marcus Oliveira
Pharmacology Department, Biological Sciences Institute, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil; Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros (UNIMONTES), Montes Claros, Minas Gerais, Brazil.
Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros (UNIMONTES), Montes Claros, Minas Gerais, Brazil.
Peptides. 2014 Sep;59:34-41. doi: 10.1016/j.peptides.2014.07.002. Epub 2014 Jul 10.
Angiotensin-(1-7) is one of the most important active peptides of the renin-angiotensin system (RAS) with recognized cardiovascular relevance; however several studies have shown the potential therapeutic role of Ang-(1-7) on treating and preventing metabolic disorders as well. This peptide achieves a special importance considering that in the last few decades obesity and metabolic syndrome (MS) have become a growing worldwide health problem. Angiotensin (Ang) II is the most studied component of RAS and is increased during obesity, diabetes and dyslipidemia (MS); some experimental evidence has shown that Ang II modulates appetite and metabolism as well as mechanisms that induce adipose tissue growth and metabolism in peripheral organs. Recent articles demonstrated that Ang-(1-7)/Mas axis modulates lipid and glucose metabolism and counterregulates the effects of Ang II. Based on these data, angiotensin-converting enzyme 2 (ACE2)/Ang-(1-7)/Mas pathway activation have been advocated as a new tool for treating metabolic diseases. This review summarizes the new evidence from animal and human experiments indicating the use of Ang-(1-7) in prevention and treatment of obesity and metabolic disorders.
血管紧张素 -（1 - 7）是肾素 - 血管紧张素系统（RAS）中最重要的活性肽之一，具有公认的心血管相关性；然而，多项研究表明，血管紧张素 -（1 - 7）在治疗和预防代谢紊乱方面也具有潜在的治疗作用。考虑到在过去几十年中，肥胖和代谢综合征（MS）已成为全球日益严重的健康问题，这种肽变得尤为重要。血管紧张素（Ang）II是RAS中研究最多的成分，在肥胖、糖尿病和血脂异常（MS）期间会升高；一些实验证据表明，Ang II可调节食欲和代谢，以及诱导外周器官脂肪组织生长和代谢的机制。最近的文章表明，血管紧张素 -（1 - 7）/Mas轴可调节脂质和葡萄糖代谢，并对抗Ang II的作用。基于这些数据，血管紧张素转换酶2（ACE2）/血管紧张素 -（1 - 7）/Mas途径的激活已被提倡作为治疗代谢疾病的新工具。本综述总结了来自动物和人体实验的新证据，表明血管紧张素 -（1 - 7）在预防和治疗肥胖及代谢紊乱方面的应用。
