Cai Bin, Wu Zhenjie, Liao Kai, Zhang Sen
Department of Colorectal Surgery, First Affiliated Hospital of Guangxi Medical University, 22 Shuangyong Road, Nanning, 530021, Guangxi, People's Republic of China.
Tumour Biol. 2014 Sep;35(9):8445-50. doi: 10.1007/s13277-014-2311-4. Epub 2014 Jul 14.
A number of studies have reported that HOTAIR expression levels were higher in cancerous tissues than in corresponding noncancerous tissues and overexpression of HOTAIR was prone to lymph node metastasis. This meta-analysis collected all relevant articles and explored the association between HOTAIR expression levels with lymph node metastasis. A literature collection was conducted by searching electronic databases PubMed, Cochrane Library, OVID, Web of Science, and CNKI (up to March 22, 2014). The odds ratio (OR) and its corresponding 95 % confidence interval (CI) were calculated to assess the strength of the association by using RevMan5.2 software. A total of 748 patients from 8 studies were included in this meta-analysis. The results showed there was a significant difference in the incidence of lymph node metastasis between high HOTAIR expression group and low HOTAIR expression group (OR = 2.81, 95 % CI 1.38-5.70, P = 0.004 random-effects model). This meta-analysis demonstrated that the incidence of lymph node metastasis in patients detected with high HOTAIR expression was higher than that in patients with low HOTAIR expression.
多项研究报道，HOTAIR在癌组织中的表达水平高于相应的癌旁组织，且HOTAIR过表达易于发生淋巴结转移。本荟萃分析收集了所有相关文章，探讨HOTAIR表达水平与淋巴结转移之间的关联。通过检索电子数据库PubMed、Cochrane图书馆、OVID、科学网和中国知网（截至2014年3月22日）进行文献收集。使用RevMan5.2软件计算比值比（OR）及其相应的95%置信区间（CI），以评估关联强度。本荟萃分析共纳入来自8项研究的748例患者。结果显示，HOTAIR高表达组与低表达组之间淋巴结转移发生率存在显著差异（OR = 2.81，95%CI 1.38 - 5.70，随机效应模型P = 0.004）。本荟萃分析表明，检测到HOTAIR高表达的患者淋巴结转移发生率高于HOTAIR低表达的患者。
