Neoplasma. 2018;65(2):178-184. doi: 10.4149/neo_2018_170114N34.
HOTAIR has been reported to be associated with development and metastasis in different types of cancer. This meta- analysis collected all relevant articles and explored the correlation of HOTAIR with lymph node metastasis (LNM) and distant metastasis (DM). A literature collection was conducted by searching PubMed, Web of Science, Google Scholar and Cochrane Library (up to Sep 11, 2016). The odds ratio (OR) with 95% confidence interval (95% CI) was calculated to assess the association with strength. Nineteen studies were included in this study, with a total of 1874 patients. The study objects were all Asians. We found high HOTAIR expression in tumor tissues was significantly correlated with LNM and DM, and analysis showed a pooled OR of 3.18 (95% CI: 2.10-4.81, p<0.00001) and 3.93 (95% CI: 2.39-6.47, p<0.00001), respectively. HOTAIR may serve as a novel diagnostic biomarker for cancer metastasis.
HOTAIR 已被报道与不同类型癌症的发展和转移有关。本荟萃分析收集了所有相关文献，探讨了 HOTAIR 与淋巴结转移（LNM）和远处转移（DM）的相关性。通过检索 PubMed、Web of Science、Google Scholar 和 Cochrane Library（截至 2016 年 9 月 11 日）进行文献收集。计算优势比（OR）及其 95%置信区间（95%CI）以评估相关性的强度。本研究共纳入 19 项研究，共 1874 例患者。研究对象均为亚洲人。我们发现肿瘤组织中 HOTAIR 表达升高与 LNM 和 DM 显著相关，分析显示合并 OR 分别为 3.18（95%CI：2.10-4.81，p<0.00001）和 3.93（95%CI：2.39-6.47，p<0.00001）。HOTAIR 可能成为癌症转移的新型诊断生物标志物。
