Torres Maria Jose, Barrionuevo Esther, Kowalski Marek, Blanca Miguel
Allergy Unit, University Hospital-IBIMA, Malaga 29008, Spain.
Department of Immunology Rheumatology and Allergy, Medical University of Lodz, Lodz, Poland; Department of Immunology, Rheumatology & Allergy, Chair of Clinical Immunology and Microbiology, Medical University of Lodz, 251 Pomorska Street Blg 5, Lodz 92213, Poland.
Immunol Allergy Clin North Am. 2014 Aug;34(3):507-24, vii-viii. doi: 10.1016/j.iac.2014.04.001.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the drugs most commonly involved in hypersensitivity drug reactions. Such reactions can be due to the release of inflammatory mediators in the absence of specific immunologic recognition, or immunoglobulin E (IgE)- or T-cell-selective responses. The former include upper and lower airway symptoms in patients with chronic underlying respiratory disease, the exacerbation of chronic spontaneous urticaria, and the induction of cutaneous symptoms. The latter include selective responses to a single NSAID with good tolerance to strong cyclooxygenase-1 inhibitors, with a putative IgE or T-cell mechanism proposed. These reactions can be acute or delayed.
非甾体抗炎药（NSAIDs）是最常引发药物超敏反应的药物。此类反应可能是由于在缺乏特异性免疫识别的情况下炎症介质的释放，或免疫球蛋白E（IgE）或T细胞选择性反应所致。前者包括患有慢性基础呼吸道疾病患者的上、下呼吸道症状、慢性自发性荨麻疹的加重以及皮肤症状的诱发。后者包括对单一NSAID的选择性反应，对强效环氧化酶-1抑制剂耐受性良好，并提出了假定的IgE或T细胞机制。这些反应可以是急性的或延迟的。
