ω-3多不饱和脂肪酸衍生的脂质代谢产物对血管生成、炎症和癌症的影响
ω-3 polyunsaturated fatty acids-derived lipid metabolites on angiogenesis, inflammation and cancer.
作者信息
Wang Weicang, Zhu Julia, Lyu Fei, Panigrahy Dipak, Ferrara Katherine W, Hammock Bruce, Zhang Guodong
机构信息
Department of Food Science, University of Massachusetts-Amherst, Amherst, MA 01003, United States.
Center for Vascular Biology Research and Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, United States.
出版信息
Prostaglandins Other Lipid Mediat. 2014 Oct;113-115:13-20. doi: 10.1016/j.prostaglandins.2014.07.002. Epub 2014 Jul 11.
Abstract
Epidemiological and pre-clinical studies support the anti-tumor effects of ω-3 PUFAs; however, the results from human trials are mixed, making it difficult to provide dietary guidelines or recommendations of ω-3 PUFAs for disease prevention or treatment. Understanding the molecular mechanisms by which ω-3 PUFAs inhibit cancer could lead to better nutritional paradigms and human trials to clarify their health effects. The ω-3 PUFAs exert their biological activities mainly through the formation of bioactive lipid metabolites. Here we discuss the biology of cyclooxygenase, lipoxygenase and cytochrome P450 enzymes-derived ω-3-series lipid metabolites on angiogenesis, inflammation and cancer.
摘要
流行病学和临床前研究支持ω-3多不饱和脂肪酸的抗肿瘤作用；然而，人体试验的结果参差不齐，因此难以提供关于ω-3多不饱和脂肪酸用于疾病预防或治疗的饮食指南或建议。了解ω-3多不饱和脂肪酸抑制癌症的分子机制可能会带来更好的营养模式，并开展人体试验以阐明其健康影响。ω-3多不饱和脂肪酸主要通过形成生物活性脂质代谢产物发挥其生物学活性。在此，我们讨论环氧化酶、脂氧合酶和细胞色素P450酶衍生的ω-3系列脂质代谢产物在血管生成、炎症和癌症方面的生物学特性。
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Nature. 2014 Jun 5;510(7503):92-101. doi: 10.1038/nature13479.
2
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J Cardiovasc Pharmacol. 2014 Jul;64(1):87-99. doi: 10.1097/FJC.0000000000000094.
3
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Cancer Lett. 2014 Jun 28;348(1-2):1-11. doi: 10.1016/j.canlet.2014.03.010. Epub 2014 Mar 18.
4
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J Lipid Res. 2014 Jun;55(6):1150-64. doi: 10.1194/jlr.M047357. Epub 2014 Mar 16.
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Arterioscler Thromb Vasc Biol. 2014 Mar;34(3):581-6. doi: 10.1161/ATVBAHA.113.302927. Epub 2014 Jan 23.
6
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J Exp Med. 2014 Feb 10;211(2):281-95. doi: 10.1084/jem.20131494. Epub 2014 Jan 20.
7
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8
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9
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