一种具有长发光寿命、可激活、极性依赖性的双发光成像剂。
An activatable, polarity dependent, dual-luminescent imaging agent with a long luminescence lifetime.
作者信息
Rood Marcus T M, Oikonomou Maria, Buckle Tessa, Raspe Marcel, Urano Yasuteru, Jalink Kees, Velders Aldrik H, van Leeuwen Fijs W B
机构信息
Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
出版信息
Chem Commun (Camb). 2014 Sep 4;50(68):9733-6. doi: 10.1039/c4cc04015e.
PMID:25019263
Abstract
In this proof-of-concept study, a new activatable imaging agent based on two luminophores and two different quenching mechanisms is reported. Both partial and total activation of the luminescence signal can be achieved, either in solution or in vitro. Bond cleavage makes the compound suitable for luminescence lifetime imaging.
摘要
在这项概念验证研究中，报道了一种基于两种发光体和两种不同猝灭机制的新型可激活成像剂。无论是在溶液中还是体外，都可以实现发光信号的部分和完全激活。键断裂使该化合物适用于发光寿命成像。
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