Korting H C, Seitz R, Kreller W
Department of Dermatology, Ludwig-Maximilians-University, Munich, Fed. Rep. of Germany.
Arzneimittelforschung. 1989 Apr;39(4):428-31.
Both cefotiam and ceftizoxime stimulate the uptake of gonococci by polymorphonuclear granulocytes in vitro as can be seen by light microscopy. Although this already holds true of antibiotic concentrations lower than the minimum inhibitory concentration (MIC: 1/4 x) this effect is much more marked at concentrations highly exceeding the MIC (4000 x). As light microscopic investigation allows the analysis of large numbers of cells but no final judgement on actual bacterial engulfment definite phagocytosis is demonstrated by electron microscopy.
头孢替安和头孢唑肟在体外均能刺激多形核粒细胞摄取淋球菌，这一点通过光学显微镜即可观察到。尽管抗生素浓度低于最低抑菌浓度（MIC：1/4倍）时就已经出现这种情况，但在浓度远高于MIC（4000倍）时，这种效应更为显著。由于光学显微镜检查能够分析大量细胞，但无法对实际的细菌吞噬作用做出最终判断，因此通过电子显微镜证实了明确的吞噬作用。
