Korting H C, Weber K
Arzneimittelforschung. 1987 Feb;37(2):135-8.
A wide variety of morphological changes is induced in gonococci exposed to subinhibitory concentrations of cefotiam. The spectrum reaches from phenomena like enlargement or lysis of cells which can already be seen on the light microscopic level to others which can only be detected by ultrastructural analysis. Most of the changes rarely also occur during the life cycle of gonococci not exposed to an antibiotic. Yet they are more frequent and also more distinct even in the presence of rather low concentrations of cefotiam. The development of mixed (layered and tubular) and even further disorganized mesosomes, however, seems to be characteristic of antibiotic interference.
暴露于亚抑菌浓度头孢替安的淋球菌会引发多种形态学变化。其范围涵盖从细胞肿大或溶解等在光学显微镜水平就能观察到的现象，到只能通过超微结构分析检测到的其他现象。大多数变化在未接触抗生素的淋球菌生命周期中也极少发生。然而，即便在存在相当低浓度头孢替安的情况下，这些变化更为频繁且更为明显。不过，混合（层状和管状）甚至进一步紊乱的中介体的形成似乎是抗生素干扰的特征。
