Leonardi M S, Garotta F, Berlinghieri M C, Bonina L, Mastroeni P
Institute of Microbiology, University of Messina, Italy.
Chemioterapia. 1987 Dec;6(6):417-9.
In the last few years the interest about the influence on host/parasite relations exerted by antibiotics has increased. In this study we have studied the effect of ceftizoxime, a third generation cephalosporin, on some functional parameters of human macrophages and granulocytes. Ceftizoxime does not seem to exert any stimulatory effect on phagocytosis and chemotaxis, but at the same time it allows these cells to explicate their functions during an infective process. A separate series of experiments was designed in order to investigate the immunogenicity of ceftizoxime and its immunological cross-reactivity versus other beta-lactam antibiotics. The low ELISA title of ceftizoxime indicates its weak immunogenic power. Cross-reactivity was also very low (title 1:25) when ceftizoxime was tested against the other antibiotics.
在过去几年中，人们对抗生素对宿主/寄生虫关系影响的关注度有所增加。在本研究中，我们研究了第三代头孢菌素头孢唑肟对人类巨噬细胞和粒细胞某些功能参数的影响。头孢唑肟似乎对吞噬作用和趋化性没有任何刺激作用，但同时它能使这些细胞在感染过程中发挥其功能。为了研究头孢唑肟的免疫原性及其与其他β-内酰胺类抗生素的免疫交叉反应性，我们设计了一系列单独的实验。头孢唑肟的ELISA效价较低，表明其免疫原性较弱。当头孢唑肟与其他抗生素进行测试时，交叉反应性也非常低（效价为1:25）。
