Bilgel Murat, An Yang, Lang Andrew, Prince Jerry, Ferrucci Luigi, Jedynak Bruno, Resnick Susan M
Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Alzheimers Dement. 2014 Nov;10(6):735-742.e4. doi: 10.1016/j.jalz.2014.04.520. Epub 2014 Jul 14.
The delineation of the relative temporal trajectories of specific cognitive measures associated with Alzheimer's disease (AD) is important for evaluating preclinical markers and monitoring disease progression.
We characterized the temporal trajectories of measures of verbal episodic memory, short-term visual memory, and mental status using data from 895 participants in the Baltimore Longitudinal Study of Aging.
The California Verbal Learning Test (CVLT) immediate recall was the first measure to decline, followed by CVLT delayed recall. However, further along the disease progression scale, CVLT delayed recall and visual memory changed more rapidly than CVLT immediate recall.
Our findings reconcile reports of early changes in immediate recall with greater reliance on delayed recall performance in clinical settings. Moreover, the utility of cognitive markers in evaluating AD progression depends on the stage of cognitive decline, suggesting that optimal endpoints in therapeutic trials may vary across different stages of the disease process.
明确与阿尔茨海默病（AD）相关的特定认知指标的相对时间轨迹，对于评估临床前标志物和监测疾病进展至关重要。
我们利用巴尔的摩纵向衰老研究中895名参与者的数据，对言语情景记忆、短期视觉记忆和精神状态指标的时间轨迹进行了特征描述。
加利福尼亚言语学习测验（CVLT）即时回忆是首个出现下降的指标，其次是CVLT延迟回忆。然而，在疾病进展量表上进一步观察发现，CVLT延迟回忆和视觉记忆的变化比CVLT即时回忆更快。
我们的研究结果协调了即时回忆早期变化的报告与临床环境中对延迟回忆表现的更大依赖。此外，认知标志物在评估AD进展中的效用取决于认知衰退的阶段，这表明治疗试验中的最佳终点可能因疾病过程的不同阶段而异。
