Fraser I S, Lun Z G, Zhou J P, Herington A C, McCarron G, Caterson I, Tan K, Markham R
Department of Obstetrics and Gynecology, University of Sydney, New South Wales, Australia.
J Clin Endocrinol Metab. 1989 Sep;69(3):585-92. doi: 10.1210/jcem-69-3-585.
Six women with elevated circulating levels of big big PRL (BBPRL) and apparently normal ovarian function were variously studied through a menstrual cycle and menstruation, through pregnancy and suckling, and during stimulation tests with TRH and suppression with bromocriptine. No significant changes in monomeric PRL were demonstrated during the menstrual cycle, but all subjects showed a small and significant rise in BBPRL during the preovulatory phase. High PRL levels were present in day 1 menstrual plasma, but BBPRL was only present in low concentrations. All subjects (n = 5) demonstrated a rise in both PRL and BBPRL during pregnancy, with a consistent tendency for PRL to increase to a proportionately greater extent than BBPRL. One subject exhibited a rise in PRL (by 93%), but not BBPRL, 30 min after suckling. TRH caused a brisk rise in PRL (by 363 +/- 116%) but only a sluggish rise in BBPRL (by 17.5 +/- 7.4%; n = 3). Bromocriptine rapidly suppressed PRL (by 81.8 +/- 34.4%), but only slowly suppressed BBPRL (by 21.0 +/- 8.7% after 6 h; n = 3). Plasma binding studies did not demonstrate any evidence of a circulating specific PRL-binding protein. These data indicate that plasma concentrations of BBPRL may vary under the influence of a number of factors, but are much less sensitive to TRH stimulation, bromocriptine suppression, pregnancy, and suckling than PRL. The occurrence of BBPRL does not seem to be due to a specific circulating binding protein.
对6名循环血中大巨泌乳素（BBPRL）水平升高但卵巢功能明显正常的女性，在整个月经周期和经期、孕期和哺乳期以及促甲状腺激素释放激素（TRH）刺激试验和溴隐亭抑制试验期间进行了多方面研究。月经周期中单体泌乳素未显示出显著变化，但所有受试者在排卵前期BBPRL均有小幅但显著升高。月经第1天血浆中泌乳素水平较高，但BBPRL仅以低浓度存在。所有受试者（n = 5）在孕期泌乳素和BBPRL均升高，泌乳素升高幅度始终比BBPRL大。1名受试者在哺乳后30分钟泌乳素升高（升高93%），但BBPRL未升高。TRH使泌乳素迅速升高（升高363 +/- 116%），但BBPRL仅缓慢升高（升高17.5 +/- 7.4%；n = 3）。溴隐亭迅速抑制泌乳素（抑制81.8 +/- 34.4%），但仅缓慢抑制BBPRL（6小时后抑制21.0 +/- 8.7%；n = 3）。血浆结合研究未显示存在循环特异性泌乳素结合蛋白的任何证据。这些数据表明，BBPRL的血浆浓度可能受多种因素影响而变化，但与泌乳素相比，其对TRH刺激、溴隐亭抑制、怀孕和哺乳的敏感性要低得多。BBPRL的出现似乎并非由于特异性循环结合蛋白所致。
