Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Cell. 2014 Jul 17;158(2):464-464.e1. doi: 10.1016/j.cell.2014.06.041.
Regulated necrosis, termed necroptosis, is mediated by the kinase activity of RIPK1 and RIPK3. It has distinct cellular features that are different than apoptosis. Necroptosis can be triggered by extracellular stimuli known to activate inflammation and cell death and its intracellular signaling pathway involves necrosome formation and MLKL activation. Inhibition of necroptosis has been shown to mitigate pathology in numerous mouse models, providing potential strategies to treat human diseases.
受调控的细胞坏死，也被称为程序性坏死，由 RIPK1 和 RIPK3 的激酶活性所介导。程序性坏死具有不同于细胞凋亡的独特细胞特征。细胞外刺激可以引发程序性坏死，已知这些刺激会激活炎症和细胞死亡，其细胞内信号通路涉及坏死小体的形成和 MLKL 的激活。抑制程序性坏死已被证明可以减轻许多小鼠模型中的病理学，为治疗人类疾病提供了潜在策略。
