Miao Yan-Dong, Quan Wuxia, Dong Xin, Gan Jian, Ji Cui-Feng, Wang Jiang-Tao, Zhang Fang
The Cancer Center, Yantai Affiliated Hospital of Binzhou Medical University, The 2nd Medical College of Binzhou Medical University, Yantai, 264100, China.
Yantai Affiliated Hospital of Binzhou Medical University, The 2nd Medical College of Binzhou Medical University, Yantai, 264100, China.
Cell Death Discov. 2023 Apr 15;9(1):129. doi: 10.1038/s41420-023-01421-1.
This study aims to visualize research hotspots and trends of "ferroptosis in cancer", "necroptosis in cancer", "pyroptosis in cancer", and "cuproptosis in cancer" through a bibliometric analysis to facilitate understanding of future developments in basic and clinical research and to provide a new perspective on cancer treatment. From January 1, 2012 to October 31, 2022, in the field of "ferroptosis in cancer", a total of 2467 organizations from 79 different countries published 3302 articles. 2274 organizations from 72 different countries published 2233 articles in the field of " necroptosis in cancer". 1366 institutions from 58 different countries contributed 1445 publications in the field of "pyroptosis in cancer". In the field of " cuproptosis in cancer", the number of articles published in the last 10 years is relatively low, with a total of 109 articles published by 116 institutions from four different countries. In the field of "ferroptosis in cancer", Tang Daolin had published 66 documents, ranked the first, while Dixon SJ is the most cited author, cited 3148 times; In the fields of "necroptosis in cancer", Vandenabeele peter had published 35 papers and Degterev had been cited 995 times, ranked the first, respectively; Kanneganti thirumala-devi had published 24 papers, is the highest number of publications in the fields of "pyroptosis in cancer", while Shi JJ was the most cited author with being cited 508 times. Both Huang Yan and Wang Tao published three papers and tied for first place and Tsvetkov p ranks first with being cited 107 times in "cuproptosis in cancer". "Cell", "Cell", "Nature", and "Science" was the most frequently co-cited journal on "ferroptosis in cancer", "necroptosis in cancer", "pyroptosis in cancer", and "cuproptosis in cancer", respectively. Further exploration of inhibitors of different Programmed cell death (PCD) and their targeted therapies are potential treatment options for cancer, but more direct clinical evidence as well as higher level clinical trials remain to be explored. Further clarification of the mechanisms of crosstalk between these PCDs may provide effective cancer treatments. And the role of different types of PCDs, especially the novel ones discovered, in cancer can be expected to remain a hot topic of research in the cancer field for quite some time to come.
本研究旨在通过文献计量分析可视化“癌症中的铁死亡”“癌症中的坏死性凋亡”“癌症中的焦亡”和“癌症中的铜死亡”的研究热点和趋势，以促进对基础和临床研究未来发展的理解，并为癌症治疗提供新视角。2012年1月1日至2022年10月31日，在“癌症中的铁死亡”领域，来自79个不同国家的2467个组织发表了3302篇文章。在“癌症中的坏死性凋亡”领域，来自72个不同国家的2274个组织发表了2233篇文章。在“癌症中的焦亡”领域，来自58个不同国家的1366个机构发表了1445篇论文。在“癌症中的铜死亡”领域，过去10年发表的文章数量相对较少，共有来自4个不同国家的116个机构发表了109篇文章。在“癌症中的铁死亡”领域，唐道林发表了66篇文献，排名第一，而迪克森·SJ是被引用次数最多的作者，被引用3148次；在“癌症中的坏死性凋亡”领域，范德内贝勒·彼得发表了35篇论文，德格捷列夫被引用995次，分别排名第一；坎内甘蒂·蒂鲁马拉-德维发表了24篇论文，是“癌症中的焦亡”领域发表论文数量最多的，而石JJ是被引用次数最多的作者，被引用508次。黄炎和王涛都发表了3篇论文并列第一，在“癌症中的铜死亡”领域，茨韦特科夫·P以被引用107次排名第一。《细胞》《细胞》《自然》和《科学》分别是“癌症中的铁死亡”“癌症中的坏死性凋亡”“癌症中的焦亡”和“癌症中的铜死亡”领域被共同引用最频繁的期刊。进一步探索不同程序性细胞死亡（PCD）的抑制剂及其靶向治疗是癌症的潜在治疗选择，但仍有待探索更直接的临床证据以及更高水平的临床试验。进一步阐明这些PCD之间的相互作用机制可能会提供有效的癌症治疗方法。并且不同类型的PCD，尤其是新发现的类型，在癌症中的作用预计在未来相当长一段时间内仍将是癌症领域的研究热点。
