Collaborative Innovation Center for Marine Biomass Fibers, Materials and Textiles of Shandong Province, Laboratory of New Fiber Materials and Modern Textile, Growing Basis for State Key Laboratory, College of Chemistry, Chemical Engineering and Environment, Qingdao University, Qingdao 266071, China.
Collaborative Innovation Center for Marine Biomass Fibers, Materials and Textiles of Shandong Province, Laboratory of New Fiber Materials and Modern Textile, Growing Basis for State Key Laboratory, College of Chemistry, Chemical Engineering and Environment, Qingdao University, Qingdao 266071, China.
Carbohydr Polym. 2014 Oct 13;111:393-9. doi: 10.1016/j.carbpol.2014.05.002. Epub 2014 May 10.
Porous microspheres of regenerated cellulose with size in range of 1-2 μm and composite microspheres of chitosan coated cellulose with size of 1-3 μm were obtained through a two-step spray-assisted approach. The spray coagulating process must combine with a spray drying step to guarantee the formation of stable microspheres of cellulose. This approach exhibits the following two main virtues. First, the preparation was performed using aqueous solution of cellulose as precursor in the absence of organic solvent and surfactant; Second, neither crosslinking agent nor separated crosslinking process was required for formation of stable microspheres. Moreover, the spray drying step also provided us with the chance to encapsulate guests into the resultant cellulose microspheres. The potential application of the cellulose microspheres acting as drug delivery vector has been studied in two PBS (phosphate-buffered saline) solution with pH values at 4.0 and 7.4 to mimic the environments of stomach and intestine, respectively.
通过两步喷雾辅助法获得了粒径在 1-2μm 范围内的再生纤维素多孔微球和粒径在 1-3μm 范围内的壳聚糖涂覆纤维素复合微球。喷雾凝固过程必须与喷雾干燥步骤相结合，以保证纤维素稳定微球的形成。该方法具有以下两个主要优点。首先，制备过程使用纤维素的水溶液作为前体，不使用有机溶剂和表面活性剂；其次，形成稳定的微球不需要交联剂也不需要单独的交联过程。此外，喷雾干燥步骤还为我们提供了将客体包封到所得纤维素微球中的机会。研究了纤维素微球作为药物传递载体的潜在应用，在 pH 值分别为 4.0 和 7.4 的两种 PBS（磷酸盐缓冲盐水）溶液中进行了研究，分别模拟胃和肠的环境。
