Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002, Basel, Switzerland; University of Basel, Basel, Switzerland.
Br J Dermatol. 2014 Dec;171(6):1533-6. doi: 10.1111/bjd.13248. Epub 2014 Nov 9.
The ribosomal protein S6 is part of the translation machinery and is activated by phosphorylation via the mammalian target of rapamycin pathway, which is activated in psoriatic skin.
To investigate which S6 sites are phosphorylated in psoriasis and atopic dermatitis (AD), and to study whether S6 phosphorylation is associated with inflammation and/or keratinocyte hyperproliferation.
Healthy skin and skin lesions of patients with psoriasis and AD were investigated by immunostaining using antibodies that stain proliferating cells, leucocytes and distinct phosphorylated sites of S6.
All psoriasis and AD lesions revealed abnormal S6 phosphorylation in the epidermis. The extent of S6 phosphorylation was diverse, generally stronger in psoriasis and correlated, in both diseases, with inflammation. S6 showed differential phosphorylation in distinct epidermal layers, which was most pronounced in hyperproliferative regions.
Differential S6 phosphorylation may have a role in abnormal keratinocyte proliferation/differentiation.
核糖体蛋白 S6 是翻译机制的一部分，可通过哺乳动物雷帕霉素靶蛋白（mTOR）通路磷酸化激活，该通路在银屑病皮肤中被激活。
研究银屑病和特应性皮炎（AD）中哪些 S6 位点被磷酸化，并研究 S6 磷酸化是否与炎症和/或角质形成细胞过度增殖有关。
使用可标记增殖细胞、白细胞和 S6 不同磷酸化位点的抗体，通过免疫染色法对健康皮肤和银屑病及 AD 患者的皮损进行研究。
所有银屑病和 AD 皮损的表皮均显示 S6 异常磷酸化。S6 磷酸化的程度不同，在银屑病中通常更强，且在两种疾病中均与炎症相关。S6 在不同的表皮层中呈现出差异磷酸化，在过度增殖的区域最为明显。
S6 的差异磷酸化可能在异常角质形成细胞增殖/分化中起作用。
