Vässin H, Vielmetter J, Campos-Ortega J A
J Neurogenet. 1985 Nov;2(5):291-308. doi: 10.3109/01677068509102325.
A number of genetic loci, called neurogenic, have been found to be involved in directing the segregation of neural and epidermal lineages within the ectodermal germ layer of Drosophila melanogaster. With the aim of understanding the regulation of this developmental function we have studied interactions of the loci N, Dl and E(spl) among each other and with another locus (H), by means of increasing and decreasing the number of wild-type copies of one of these genes in the presence of mutations in another one. The results reveal functional community which exists among these neurogenic loci. E(spl) overlaps functionally with both N and Dl because genotypes involving only one copy of E(spl)+ and either an N or Dl mutation are lethal. Furthermore the normal H+ allele behaves as if it represses the activity of the 3 neurogenic loci; and, whereas E(spl) seems to be a close target of H repressing action, the influence of H upon the other two seems to be indirect.
已发现一些被称为神经源的基因座参与指导黑腹果蝇外胚层胚层内神经和表皮谱系的分离。为了理解这种发育功能的调控，我们通过在另一个基因发生突变的情况下增加或减少其中一个基因的野生型拷贝数，研究了基因座N、Dl和E(spl)之间以及它们与另一个基因座(H)之间的相互作用。结果揭示了这些神经源基因座之间存在功能群落。E(spl)在功能上与N和Dl重叠，因为仅涉及一个E(spl)+拷贝以及N或Dl突变的基因型是致死的。此外，正常的H+等位基因表现得好像它抑制了这3个神经源基因座的活性；而且，虽然E(spl)似乎是H抑制作用的直接靶点，但H对另外两个基因座的影响似乎是间接的。
