Food and Health Programme, Institute of Food Research, Norwich Research Park, Norwich, NR4 7UA, UK.
Food and Health Programme, Institute of Food Research, Norwich Research Park, Norwich, NR4 7UA, UK.
Drug Discov Today. 2014 Sep;19(9):1488-92. doi: 10.1016/j.drudis.2014.07.007. Epub 2014 Jul 19.
Whereas much attention is focused on distinguishing newly diagnosed prostate cancers that will progress to become aggressive forms of the disease from those that will remain indolent, it is also appropriate to explore therapeutic and lifestyle interventions to reduce the risk of progression. Diets rich in broccoli have been associated with a reduction in risk of progression, which has been attributed to the compound sulforaphane. Although the mode of action of sulforaphane has been extensively studied in cell and animal models and a multiple of mechanisms that could underpin its protective effects have been proposed, recent evidence from human intervention studies suggests that sulforaphane is involved in a complex interplay between redox status and metabolism to result in a tissue environment that does not favour prostate cancer progression.
虽然人们非常关注区分新诊断的前列腺癌，这些前列腺癌将发展为侵袭性疾病形式，与那些将保持惰性的前列腺癌，但探索治疗和生活方式干预以降低进展风险也是合适的。富含西兰花的饮食与降低进展风险有关，这归因于化合物萝卜硫素。尽管萝卜硫素的作用模式在细胞和动物模型中得到了广泛研究，并提出了多种可能支持其保护作用的机制，但来自人类干预研究的最新证据表明，萝卜硫素参与了氧化还原状态和代谢之间的复杂相互作用，导致不利于前列腺癌进展的组织环境。
