Shanks N, Anisman H
Department of Psychology, Carleton University, Ottawa, Ontario, Canada.
Psychopharmacology (Berl). 1989;99(1):122-8. doi: 10.1007/BF00634465.
The effects of several antidepressants (desmethylimipramine, amitriptyline and bupropion) on escape deficits induced by inescapable shock were assessed in four strains of mice. The extent of the escape interference engendered by inescapable shock varied across strains of mice. These deficits of escape performance were differentially affected by the drug treatments across strains. Repeated administration of desmethylimipramine eliminated the escape interference in A/J, but did not affect the performance in Balb/cByJ, C57BL/6J or CD-1 mice. Bupropion, in contrast, had a modest effect only in CD-1 mice. Unlike these compounds, the 5-HT reuptake blocker, amitriptyline, was found to influence escape performance irrespective of whether the drug was acutely or chronically applied. It is suggested that (a) the relative contributions of various mechanisms subserving the escape interference may vary across strains of mice, hence accounting for the strain-specific effects of the drug treatments, and (b) various antidepressants influence performance by affecting different components of the behavioral output, some of which may be apparent after acute treatment while others are expressed only after repeated treatment with the compound.
在四种品系的小鼠中评估了几种抗抑郁药（去甲丙咪嗪、阿米替林和安非他酮）对不可逃避电击诱导的逃避缺陷的影响。不可逃避电击产生的逃避干扰程度在不同品系的小鼠中有所不同。这些逃避表现的缺陷在不同品系中受到药物治疗的不同影响。重复给予去甲丙咪嗪消除了A/J小鼠的逃避干扰，但对Balb/cByJ、C57BL/6J或CD-1小鼠的表现没有影响。相比之下，安非他酮仅对CD-1小鼠有适度影响。与这些化合物不同，5-羟色胺再摄取阻滞剂阿米替林被发现无论急性还是慢性给药都会影响逃避表现。有人提出：（a）各种促成逃避干扰的机制的相对作用在不同品系的小鼠中可能有所不同，因此可以解释药物治疗的品系特异性效应；（b）各种抗抑郁药通过影响行为输出的不同成分来影响表现，其中一些在急性治疗后可能明显，而其他一些只有在反复使用该化合物治疗后才会表现出来。
