Aguiar Júnior Samuel, Andrade Wesley Pereira, Baiocchi Glauco, Guimarães Gustavo Cardoso, Cunha Isabela Werneck, Estrada Daniel Alvarez, Suzuki Sergio Hideki, Kowalski Luiz Paulo, Lopes Ademar
Department of Pelvic Surgery, Hospital A. C. Camargo, São Paulo, Brazil.
Department of Pathology, Hospital A. C. Camargo, São Paulo, Brazil.
Sao Paulo Med J. 2014;132(5):297-302. doi: 10.1590/1516-3180.2014.1325628. Epub 2014 Jul 29.
Chordoma is a rare tumor with a high risk of locoregional recurrences. The aim of this study was analyze the long-term results from treating this pathological condition.
Cohort study in a single hospital in São Paulo, Brazil.
This was a retrospective cohort study on 42 patients with chordoma who were treated at Hospital A. C. Camargo between 1980 and 2006. The hospital records were reviewed and a descriptive analysis was performed on the clinical-pathological variables. Survival curves were estimated using the Kaplan-Meier method and these were compared using the log-rank test.
Nineteen patients were men and 23 were women. Twenty-five tumors (59.5%) were located in the sacrum, eleven (26.2%) in the skull base and six (14.3%) in the mobile spine. Surgery was performed on 28 patients (66.7%). The resection was considered to have negative margins in 14 cases and positive margins in 14 cases. The five-year overall survival (OS) was 45.4%. For surgical patients, the five-year OS was 64.3% (82.2% for negative margins and 51.9% for positive margins). In the inoperable group, OS was 37.7% at 24 months and 0% at five years.
Complete resection is related to local control and definitively has a positive impact on long-term survival.
脊索瘤是一种罕见肿瘤，局部区域复发风险高。本研究旨在分析治疗这种病理状况的长期结果。
巴西圣保罗一家医院的队列研究。
这是一项对1980年至2006年期间在A.C.卡马戈医院接受治疗的42例脊索瘤患者的回顾性队列研究。查阅医院记录并对临床病理变量进行描述性分析。使用Kaplan-Meier方法估计生存曲线，并使用对数秩检验进行比较。
19例为男性，23例为女性。25个肿瘤（59.5%）位于骶骨，11个（26.2%）位于颅底，6个（14.3%）位于活动脊柱。28例患者（66.7%）接受了手术。14例切除边缘被认为阴性，14例为阳性。五年总生存率（OS）为45.4%。对于手术患者，五年OS为64.3%（切缘阴性者为82.2%，切缘阳性者为51.9%）。在不可手术组中，24个月时OS为37.7%，五年时为0%。
完整切除与局部控制相关，并且肯定对长期生存有积极影响。
