从 microRNA 表达模式看口腔癌及其危险因素的世界。
The World of Oral Cancer and Its Risk Factors Viewed from the Aspect of MicroRNA Expression Patterns.
机构信息
Department of Oral Health, "Iuliu Hatieganu" University of Medicine and Pharmacy, 15 Victor Babeș Street, 400012 Cluj-Napoca, Romania.
Research Center for Functional Genomics, Biomedicine and Translational Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, 23 Marinescu Street, 400337 Cluj-Napoca, Romania.
出版信息
Genes (Basel). 2022 Mar 26;13(4):594. doi: 10.3390/genes13040594.
Oral cancer is one of the leading causes of death worldwide, with a reported 5-year survival rate of around 50% after treatment. Epigenetic modifications are considered to have a key role in oral carcinogenesis due to histone modifications, aberrant DNA methylation, and altered expression of miRNAs. MicroRNAs (miRNAs) are small non-coding RNAs that have a key role in cancer development by regulating signaling pathways involved in carcinogenesis. MiRNA deregulation identified in oral cancer has led to the idea of using them as potential biomarkers for early diagnosis, prognosis, and the development of novel therapeutic strategies. In recent years, a key role has been observed for risk factors in preventing and treating this malignancy. The purpose of this review is to summarize the recent knowledge about the altered mechanisms of oral cancer due to risk factors and the role of miRNAs in these mechanisms.
口腔癌是全球主要的致死原因之一，据报道，治疗后 5 年的生存率约为 50%。由于组蛋白修饰、异常的 DNA 甲基化和 miRNA 表达的改变，表观遗传修饰被认为在口腔癌发生中起关键作用。微小 RNA（miRNA）是一种小的非编码 RNA，通过调节致癌作用相关的信号通路，在癌症发展中起关键作用。在口腔癌中鉴定的 miRNA 失调导致人们认为它们可以作为早期诊断、预后和开发新的治疗策略的潜在生物标志物。近年来，风险因素在预防和治疗这种恶性肿瘤方面的作用受到了关注。本综述的目的是总结由于风险因素导致的口腔癌改变的机制以及 miRNA 在这些机制中的作用的最新知识。
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