Backus Lisa I, Belperio Pamela S, Loomis Timothy P, Mole Larry A
Lisa I. Backus, Pamela S. Belperio, Timothy P. Loomis, and Larry A. Mole are with the Department of Veterans Affairs, Office of Public Health/Population Health, Washington, DC. Lisa Backus is also with the Department of Medicine, VA Palo Alto Health Care System, Palo Alto, CA. Pamela S. Belperio is also with the Department of Pharmacy, VA Greater Los Angeles Health Care System, Los Angeles, CA.
Am J Public Health. 2014 Sep;104 Suppl 4(Suppl 4):S555-61. doi: 10.2105/AJPH.2014.302090.
We assessed HCV screening and prevalence among veterans and estimated the potential impact of complete birth cohort screening, accounting for the disparate HCV disease burden by race/ethnicity and gender.
We used the Department of Veterans Affairs (VA) Corporate Data Warehouse to identify birth dates, gender, race/ethnicity, and laboratory tests for veterans with at least 1 VA outpatient visit in 2012. We calculated HCV screening rates, prevalence, and HCV infection incident diagnosis.
Among 5,499,743 veterans, 54.7% had HCV screening through the VA. In more than 2.9 million veterans screened, HCV prevalence was 6.1% overall and highest among Blacks (11.8%), particularly Black men born in 1945 to 1965 (17.7%). HCV infection incident diagnosis in 2012 was 5.9% for men and 2.3% for women. An estimated additional 48,928 male veterans, including 12,291 Black men, and 1484 female veterans would potentially be identified as HCV infected with full birth cohort screening.
HCV prevalence was markedly elevated among veterans born in 1945 to 1965, with substantial variation by race/ethnicity and gender. Full adoption of birth cohort screening may reveal substantial numbers of veterans with previously unknown HCV infection.
我们评估了退伍军人中的丙型肝炎病毒（HCV）筛查情况及患病率，并估计了完整出生队列筛查的潜在影响，同时考虑到不同种族/族裔和性别的HCV疾病负担差异。
我们使用退伍军人事务部（VA）企业数据仓库来确定2012年至少有1次VA门诊就诊的退伍军人的出生日期、性别、种族/族裔和实验室检查结果。我们计算了HCV筛查率、患病率以及HCV感染的确诊率。
在5499743名退伍军人中，54.7%通过VA进行了HCV筛查。在超过290万接受筛查的退伍军人中，HCV总体患病率为6.1%，在黑人中最高（11.8%），尤其是1945年至1965年出生的黑人男性（17.7%）。2012年HCV感染的确诊率男性为5.9%，女性为2.3%。通过完整出生队列筛查，估计可能会额外发现48928名男性退伍军人（包括12291名黑人男性）和1484名女性退伍军人感染HCV。
1945年至1965年出生的退伍军人中HCV患病率显著升高，且存在明显的种族/族裔和性别差异。全面采用出生队列筛查可能会发现大量此前未知感染HCV的退伍军人。
