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前交叉韧带损伤的非手术或手术治疗:膝关节功能、运动参与及膝关节再损伤:特拉华-奥斯陆前交叉韧带队列研究

Nonsurgical or Surgical Treatment of ACL Injuries: Knee Function, Sports Participation, and Knee Reinjury: The Delaware-Oslo ACL Cohort Study.

作者信息

Grindem Hege, Eitzen Ingrid, Engebretsen Lars, Snyder-Mackler Lynn, Risberg May Arna

机构信息

Norwegian Research Center for Active Rehabilitation, Department of Sports Medicine, Norwegian School of Sport Sciences, P.O. Box 4014, Ullevål Stadion, 0806 Oslo, Norway. E-mail address for H. Grindem:

Norwegian Research Center for Active Rehabilitation, Department of Orthopaedics, Oslo University Hospital, Kirkeveien 166, 0407 Oslo, Norway.

出版信息

J Bone Joint Surg Am. 2014 Aug 6;96(15):1233-1241. doi: 10.2106/JBJS.M.01054.

Abstract

BACKGROUND

While there are many opinions about the expected knee function, sports participation, and risk of knee reinjury following nonsurgical treatment of injuries of the anterior cruciate ligament (ACL), there is a lack of knowledge about the clinical course following nonsurgical treatment compared with that after surgical treatment.

METHODS

This prospective cohort study included 143 patients with an ACL injury. Isokinetic knee extension and flexion strength and patient-reported knee function as recorded on the International Knee Documentation Committee (IKDC) 2000 form were collected at baseline, six weeks, and two years. Sports participation was reported monthly for two years with use of an online activity survey. Knee reinjuries were reported at the follow-up evaluations and in a monthly online survey. Repeated analysis of variance (ANOVA), generalized estimating equation (GEE) models, and Cox regression analysis were used to analyze group differences in functional outcomes, sports participation, and knee reinjuries, respectively.

RESULTS

The surgically treated patients (n = 100) were significantly younger, more likely to participate in level-I sports, and less likely to participate in level-II sports prior to injury than the nonsurgically treated patients (n = 43). There were no significant group-by-time effects on functional outcome. The crude analysis showed that surgically treated patients were more likely to sustain a knee reinjury and to participate in level-I sports in the second year of the follow-up period. After propensity score adjustment, these differences were nonsignificant; however, the nonsurgically treated patients were significantly more likely to participate in level-II sports during the first year of the follow-up period and in level-III sports over the two years. After two years, 30% of all patients had an extensor strength deficit, 31% had a flexor strength deficit, 20% had patient-reported knee function below the normal range, and 20% had experienced knee reinjury.

CONCLUSIONS

There were few differences between the clinical courses following nonsurgical and surgical treatment of ACL injury in this prospective cohort study. Regardless of treatment course, a considerable number of patients did not fully recover following the ACL injury, and future work should focus on improving the outcomes for these patients.

LEVEL OF EVIDENCE

Therapeutic Level II. See Instructions for Authors for a complete description of levels of evidence.

摘要

背景

虽然对于前交叉韧带(ACL)损伤非手术治疗后的预期膝关节功能、运动参与情况以及膝关节再次受伤风险存在诸多观点,但与手术治疗相比,关于非手术治疗后的临床病程仍缺乏了解。

方法

这项前瞻性队列研究纳入了143例ACL损伤患者。在基线、六周和两年时收集等速膝关节伸展和屈曲力量,以及国际膝关节文献委员会(IKDC)2000表格记录的患者报告的膝关节功能。通过在线活动调查,连续两年每月报告运动参与情况。在随访评估和每月在线调查中报告膝关节再次受伤情况。分别使用重复方差分析(ANOVA)、广义估计方程(GEE)模型和Cox回归分析来分析功能结果、运动参与情况和膝关节再次受伤的组间差异。

结果

与非手术治疗患者(n = 43)相比,手术治疗患者(n = 100)在受伤前年龄显著更小,更有可能参加I级运动,而参加II级运动的可能性更小。在功能结果方面没有显著的组×时间效应。粗略分析显示,手术治疗患者在随访期第二年更有可能发生膝关节再次受伤并参加I级运动。经过倾向评分调整后,这些差异不显著;然而,非手术治疗患者在随访期第一年参加II级运动以及在两年内参加III级运动的可能性显著更高。两年后,所有患者中有30%存在伸肌力量不足,31%存在屈肌力量不足,20%患者报告的膝关节功能低于正常范围,20%经历过膝关节再次受伤。

结论

在这项前瞻性队列研究中,ACL损伤非手术和手术治疗后的临床病程差异不大。无论治疗方式如何,相当一部分患者在ACL损伤后未能完全恢复,未来的工作应专注于改善这些患者的治疗结果。

证据水平

治疗性II级。有关证据水平的完整描述,请参阅作者指南。

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