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膳食盐与心血管疾病的权衡：钠/钾-ATP 酶信号的作用？

The Trade-Off between Dietary Salt and Cardiovascular Disease; A Role for Na/K-ATPase Signaling?

机构信息

Department of Medicine, University of Colorado School of Medicine , Aurora, CO , USA.

Department of Medicine, University of Toledo College of Medicine , Toledo, OH , USA.

出版信息

Front Endocrinol (Lausanne). 2014 Jul 17;5:97. doi: 10.3389/fendo.2014.00097. eCollection 2014.

DOI:10.3389/fendo.2014.00097
PMID:25101054
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4101451/
Abstract

It has been postulated for some time that endogenous digitalis-like substances, also called cardiotonic steroids (CTS), exist, and that these substances are involved in sodium handling. Within the past 20 years, these substances have been unequivocally identified and measurements of circulating and tissue concentrations have been made. More recently, it has been identified that CTS also mediate signal transduction through the Na/K-ATPase, and consequently been implicated in profibrotic pathways. This review will discuss the mechanism of CTS in renal sodium handling and a potential "trade-off" effect from their role in inducing tissue fibrosis.

摘要

有一段时间以来，人们一直假设内源性洋地黄样物质（也称为强心甾类）的存在，并且这些物质参与钠处理。在过去的 20 年中，这些物质已经被明确识别，并且已经对循环和组织浓度进行了测量。最近，已经确定 CTS 还通过 Na/K-ATP 酶介导信号转导，因此与成纤维增生途径有关。这篇综述将讨论 CTS 在肾脏钠处理中的作用机制，以及它们在诱导组织纤维化中的作用所带来的潜在“权衡”效应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0a1/4101451/4ca300e3ce96/fendo-05-00097-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0a1/4101451/a4feea89f9a0/fendo-05-00097-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0a1/4101451/15e3c3c46e71/fendo-05-00097-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0a1/4101451/4ca300e3ce96/fendo-05-00097-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0a1/4101451/a4feea89f9a0/fendo-05-00097-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0a1/4101451/15e3c3c46e71/fendo-05-00097-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0a1/4101451/4ca300e3ce96/fendo-05-00097-g003.jpg

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