Londei M, Verhoef A, De Berardinis P, Kissonerghis M, Grubeck-Loebenstein B, Feldmann M
Charing Cross Sunley Research Centre, Hammersmith, London, England.
Proc Natl Acad Sci U S A. 1989 Nov;86(21):8502-6. doi: 10.1073/pnas.86.21.8502.
Whereas most T cells express surface CD4 or CD8 molecules, a minority lacks both. CD4-8- cells usually express the gamma delta T-cell receptor, but here we describe a population of CD4-8- T cells from the peripheral blood that express the alpha beta heterodimer. These cells have different surface antigens than gamma delta+ T cells, expressing CD5 but lacking CD16, and differ in function from gamma delta+ T cells. CD4-8- alpha beta+ cells lack non-major histocompatibility complex-restricted cytolytic function but can be induced to lyse their target cells after activation of their T-cell receptors. A peculiar characteristic of these cells is their responsiveness to interleukin 3. Since these cells have not altered their phenotype or function over a 12-month period in culture, they appear to be mature T cells. The results indicate that normal human peripheral blood contains two subsets of CD4-8- T cells, expressing either gamma delta or alpha beta receptors, that differ in function, phenotype, and growth control.
大多数T细胞表达表面CD4或CD8分子，而少数T细胞两者均不表达。CD4-CD8-细胞通常表达γδT细胞受体，但在此我们描述了一群来自外周血的CD4-CD8-T细胞，它们表达αβ异二聚体。这些细胞具有与γδ+T细胞不同的表面抗原，表达CD5但缺乏CD16，并且在功能上与γδ+T细胞不同。CD4-CD8-αβ+细胞缺乏非主要组织相容性复合体限制的溶细胞功能，但在其T细胞受体激活后可被诱导裂解其靶细胞。这些细胞的一个特殊特征是它们对白介素3有反应。由于这些细胞在培养12个月期间未改变其表型或功能，它们似乎是成熟的T细胞。结果表明，正常人外周血含有两个CD4-CD8-T细胞亚群，分别表达γδ或αβ受体，它们在功能、表型和生长控制方面存在差异。
