Prokop A, Rosenberg M Z
Adv Biochem Eng Biotechnol. 1989;39:29-71. doi: 10.1007/BFb0051951.
Purpose of this article is to review the current status of bioreactor design for mammalian cell culture. Morphological and biochemical features of two major mammalian cell groups, anchorage-dependent and independent cells are proposed as a basis for different behavior at their cultivation. Different bioreactor configurations are systematically discussed through enumerating elementary physical phenomena and through stressing their physiological significance. Special considerations are given to those areas which are inherent to mammalian cell bioreactor.
