Chen Xi, Zhao Zhen-Wen, Li Lin, Chen Xue-Jun, Xu Hui, Lou Jin-Tu, Li Lin-Jie, Du Li-Zhong, Xie Chun-Hong
Department of Cardiology, Children's Hospital, Zhejiang University School of Medicine, No.3333 Bin-Sheng Road, Bin-Jiang Dist, Hangzhou, Zhejiang, 310052, China.
Key Laboratory for Diagnosis and Treatment of Neonatal Diseases of Zhejiang Province, Hangzhou, Zhejiang, China.
Lipids Health Dis. 2015 Dec 30;14:166. doi: 10.1186/s12944-015-0167-2.
Cardiovascular damages poses risks to children with Kawasaki disease (KD). Although hypertriglyceridemia and hypercholesteremia are risk factors of cardiovascular damages, studies on the blood lipid metabolism in KD are still limited. This study aims to analyze the blood lipids and coagulation in KD.
Triglyceride (TG) and cholesterol levels in the plasma and serum from 20 children with KD were examined in comparison with 10 healthy children (HC) as well as 10 children with high fever from identified bacterial infections (BT). Using electrospray ionization mass spectrometry, we profiled the lipid species. Blood coagulation was analyzed. Statistics was analyzed by one-way ANOVA using SigmaStat.
We found that in KD, plasma TG level was significantly increased, but not serum TG. A total of 19 molecular species of TG were identified, and they were all increased in KD and BT patients, and more pronounced in KD. On the other hand, major molecular species of plasma phosphotidylcholine and lyso-phosphotidylcholine were decreased in KD and BT. Pronounced hypercoagulation was found in KD blood.
Our data indicate hyperlipidemia in KD, especially for TG, which contributes to the hypercoagulation and the potential risk of cardiovascular damages. Evaluation of blood lipid levels in severe KD patients could provide valuable information for treatment and prognosis, thus would be worthy of consideration.
心血管损伤对川崎病（KD）患儿构成风险。尽管高甘油三酯血症和高胆固醇血症是心血管损伤的危险因素，但关于KD患儿血脂代谢的研究仍然有限。本研究旨在分析KD患儿的血脂和凝血情况。
检测了20例KD患儿的血浆和血清中甘油三酯（TG）和胆固醇水平，并与10例健康儿童（HC）以及10例确诊为细菌感染的高热儿童（BT）进行比较。使用电喷雾电离质谱法对脂质种类进行了分析。对凝血情况进行了分析。使用SigmaStat软件通过单因素方差分析进行统计学分析。
我们发现，在KD患儿中，血浆TG水平显著升高，但血清TG水平未升高。共鉴定出19种TG分子种类，它们在KD和BT患儿中均升高，且在KD患儿中更为明显。另一方面，KD和BT患儿血浆磷脂酰胆碱和溶血磷脂酰胆碱的主要分子种类减少。在KD患儿血液中发现明显的高凝状态。
我们的数据表明KD患儿存在高脂血症，尤其是TG升高，这导致了高凝状态以及心血管损伤的潜在风险。评估重症KD患儿的血脂水平可为治疗和预后提供有价值的信息，因此值得考虑。
