Pasi K J, Hill F G
Department of Haematology, Children's Hospital, Birmingham.
Arch Dis Child. 1989 Oct;64(10):1463-7. doi: 10.1136/adc.64.10.1463.
Seventeen previously untreated boys with haemophilia A were treated with high purity heat treated factor VIII concentrate (8Y) for up to 36 months. Liver function tests were assessed monthly. No boy's serum has been shown to contain HIV antibodies and no increases in alanine transaminase activity have been detected. In only one patient was a single rise in aspartate transaminase activity noted, and this was without a corresponding rise in alanine transaminase. A second patient's serum contained hepatitis B core antibody transiently. It was thought likely in both cases that the abnormalities reflected intercurrent infections rather than disease associated with transfusion. The physical treatments used in the production of 8Y seem to inactivate the agent(s) responsible for non-A, non-B hepatitis and HIV transmission by transfusion of factor VIII has been abolished. There are, however, problems associated with conducting safety trials in young haemophiliac patients.
17名之前未接受过治疗的甲型血友病男孩接受了高纯度热处理的凝血因子VIII浓缩物（8Y）治疗，为期36个月。每月评估肝功能测试。未发现任何男孩的血清含有HIV抗体，也未检测到丙氨酸转氨酶活性升高。仅1例患者的天冬氨酸转氨酶活性出现单次升高，且丙氨酸转氨酶未相应升高。另1例患者的血清曾短暂含有乙肝核心抗体。在这两例中，异常情况可能反映的是并发感染，而非与输血相关的疾病。生产8Y所采用的物理处理方法似乎能使导致非甲非乙型肝炎和通过输血传播HIV的病原体失活。然而，在年轻血友病患者中进行安全性试验存在一些问题。
