Fletcher M L, Trowell J M, Craske J, Pavier K, Rizza C R
Br Med J (Clin Res Ed). 1983 Dec 10;287(6407):1754-7. doi: 10.1136/bmj.287.6407.1754.
Thirty patients who had not previously received treatment with factor VIII concentrate or who had been treated only infrequently with factor VIII concentrate were studied after a transfusion of factor VIII. Tests of liver function were performed frequently. Four patients had evidence of chronic liver disease before transfusion. In 17 of the remaining 26 patients serum transaminase activities became raised and 10 patients developed jaundice. All of the nine patients who had not previously received factor VIII transfusion developed non-A non-B hepatitis. Four out of 10 patients followed up for a year had persisting abnormalities of liver function. The pattern of illness suggests that more than one serotype of non-A non-B hepatitis virus may be transmitted by factor VIII concentrate prepared by the National Health Service from volunteer donors in the United Kingdom.
对30名此前未接受过凝血因子VIII浓缩物治疗或仅偶尔接受过凝血因子VIII浓缩物治疗的患者在输注凝血因子VIII后进行了研究。频繁进行肝功能测试。4名患者在输血前有慢性肝病的证据。在其余26名患者中，17名患者血清转氨酶活性升高，10名患者出现黄疸。所有9名此前未接受过凝血因子VIII输血的患者均患上了非甲非乙型肝炎。在随访一年的10名患者中，有4名患者肝功能持续异常。这种疾病模式表明，英国国家医疗服务体系从志愿献血者制备的凝血因子VIII浓缩物可能传播不止一种血清型的非甲非乙型肝炎病毒。
