Walkiewicz Katarzyna, Nowakowska-Zajdel Ewa, Kozieł Paweł, Muc-Wierzgoń Małgorzata
Katedra i Oddział Kliniczny Chorób Wewnętrznych, Wydział Zdrowia Publicznego w Bytomiu, Śląski Uniwersytet Medyczny w Katowicach, Polska.
Zakład Profilaktyki Chorób Żywieniowozależnych, Wydział Zdrowia Publicznego w Bytomiu, Śląski Uniwersytet Medyczny w Katowicach, Polska.
Cent Eur J Immunol. 2018;43(1):109-113. doi: 10.5114/ceji.2018.74881. Epub 2018 Mar 30.
Colorectal cancer (CRC) is the third most common malignant neoplasm worldwide. In Poland, colorectal cancer ranks second in tumor incidence regardless of sex; moreover, there has been a steady increase in the incidence of CRC. CRC results from complex interactions between inherited susceptibility, clinical conditions and environmental/lifestyle-related risk factors such as physical inactivity, smoking, alcohol consumption, high-fat/low-fiber diet, and obesity/overweight. The activation of pathways associated with insulin resistance and insulin-like growth factors (IGF) appears to be the epidemiological link between the metabolic syndrome and the development of CRC, which is of particular importance. What is significantly associated with the pathway of IGF is ADAM12 and 28-protein, which belong to a broad family of the adamalysines. These proteins, by adjusting the bioavailability of growth factors, influence the process of carcinogenesis. The aim of this article is to analyze the role of selected adamalysines and activation of the IGF system associated with the formation of colon cancer.
结直肠癌(CRC)是全球第三大常见恶性肿瘤。在波兰,无论性别,结直肠癌的发病率在肿瘤中均排名第二;此外,CRC的发病率一直在稳步上升。CRC是由遗传易感性、临床状况以及环境/生活方式相关风险因素(如身体活动不足、吸烟、饮酒、高脂肪/低纤维饮食以及肥胖/超重)之间的复杂相互作用导致的。与胰岛素抵抗和胰岛素样生长因子(IGF)相关途径的激活似乎是代谢综合征与CRC发生之间的流行病学联系,这一点尤为重要。与IGF途径显著相关的是ADAM12和28蛋白,它们属于adamalysines的广泛家族。这些蛋白质通过调节生长因子的生物利用度来影响致癌过程。本文的目的是分析选定的adamalysines的作用以及与结肠癌形成相关的IGF系统的激活。