Zarur Fabiana P, d'Almeida Luiza Vf, Novellino Anna Beatriz C, Reis Maria Fernanda Dg
Prof. Rubem David Azulay Institute of Dermatology, Santa Casa da Misericordia, Rio de Janeiro, RJ, Brazil.
Int J Trichology. 2014 Jan;6(1):25-6. doi: 10.4103/0974-7753.136756.
Pachydermoperiostosis or primary hypertropic osteoarthropathy is a rare hereditary disorder that was first described in 1868. It is characterized by digital clubbing, pachydermia (thickening of the facial skin and/or scalp), and periostosis (swelling of periarticular tissue and subperiosteal new bone formation). We report a case of a patient with the complete form of the disease, and with a unique appearance of the hair shaft and eyelashes. The authors propose a possible mechanism to justify the abnormalities observed in the patient's hair shafts regarding the metabolism of prostaglandins and its relationship with the hair follicle physiological cycle.
厚皮性骨膜病或原发性肥大性骨关节病是一种罕见的遗传性疾病，于1868年首次被描述。其特征为杵状指、厚皮症（面部皮肤和/或头皮增厚）和骨膜增生（关节周围组织肿胀和骨膜下新骨形成）。我们报告一例患有该疾病完全型且伴有独特毛干和睫毛外观的患者。作者提出了一种可能的机制，以解释在该患者毛干中观察到的异常与前列腺素代谢及其与毛囊生理周期的关系。
