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载银纳米颗粒/布洛芬的聚（L-丙交酯）纤维膜：抗感染和抗粘连作用

Silver nanoparticles/ibuprofen-loaded poly(L-lactide) fibrous membrane: anti-infection and anti-adhesion effects.

作者信息

Chen Shuai, Wang Guangda, Wu Tianyi, Zhao Xin, Liu Shen, Li Gang, Cui Wenguo, Fan Cunyi

机构信息

Department of Orthopaedics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai 200233, China.

Department of Orthopaedic, Yuhuangding Hospital of Yantai, 20 Yuhuangding East Road, Yantai 264000, China.

出版信息

Int J Mol Sci. 2014 Aug 12;15(8):14014-25. doi: 10.3390/ijms150814014.

DOI:10.3390/ijms150814014
PMID:25119863
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4159836/
Abstract

Infection caused by bacteria is one of the crucial risk factors for tendon adhesion formation. Silver nanoparticles (AgNP)-loaded physical barriers were reported to be effective in anti-infection and anti-adhesion. However, high silver load may lead to kidney and liver damages. This study was designed for Ibuprofen (IBU)-loaded poly(L-lactide) (PLLA) electrospun fibrous membranes containing a low dosage of Ag to evaluate its potential in maintaining suitable anti-infection and good anti-adhesion effects. The in vitro drug release study showed a sustained release of Ag ions and IBU from the membrane. Inferior adherence and proliferation of fibroblasts were found on the Ag4%-IBU4%-loaded PLLA electrospun fibrous membranes in comparison with pure PLLA and 4% Ag-loaded PLLA membranes. In the antibacterial test, all Ag-loaded PLLA electrospun fibrous membranes prevented the adhesion of Staphylococcus aureus and Staphylococcus epidermidis. Taken together, these results demonstrate that Ibuprofen is effective in enhancing the anti-adhesion and anti-proliferation effects of 4% Ag-loaded PLLA fibrous membrane. The medical potential of infection reduction and adhesion prevention of Ag4%-IBU4%-loaded PLLA electrospun fibrous membrane deserves to be further studied.

摘要

细菌感染是肌腱粘连形成的关键危险因素之一。据报道，负载银纳米颗粒（AgNP）的物理屏障在抗感染和抗粘连方面有效。然而，高银负载量可能会导致肾脏和肝脏损伤。本研究旨在制备负载布洛芬（IBU）的聚（L-丙交酯）（PLLA）电纺纤维膜，其含有低剂量的银，以评估其在维持适当抗感染和良好抗粘连效果方面的潜力。体外药物释放研究表明，银离子和布洛芬从该膜中持续释放。与纯PLLA和负载4%银的PLLA膜相比，在负载4%银-4%布洛芬的PLLA电纺纤维膜上发现成纤维细胞的粘附和增殖较差。在抗菌试验中，所有负载银的PLLA电纺纤维膜均能防止金黄色葡萄球菌和表皮葡萄球菌的粘附。综上所述，这些结果表明布洛芬在增强负载4%银的PLLA纤维膜的抗粘连和抗增殖作用方面是有效的。负载4%银-4%布洛芬的PLLA电纺纤维膜在减少感染和预防粘连方面的医学潜力值得进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af5b/4159836/272d7a92dc0c/ijms-15-14014-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af5b/4159836/96f674763154/ijms-15-14014-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af5b/4159836/70ceeada8d94/ijms-15-14014-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af5b/4159836/3dea3273fcb2/ijms-15-14014-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af5b/4159836/7bc49c454a14/ijms-15-14014-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af5b/4159836/38192dd7755c/ijms-15-14014-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af5b/4159836/272d7a92dc0c/ijms-15-14014-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af5b/4159836/96f674763154/ijms-15-14014-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af5b/4159836/70ceeada8d94/ijms-15-14014-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af5b/4159836/3dea3273fcb2/ijms-15-14014-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af5b/4159836/7bc49c454a14/ijms-15-14014-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af5b/4159836/38192dd7755c/ijms-15-14014-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af5b/4159836/272d7a92dc0c/ijms-15-14014-g006.jpg

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本文引用的文献

[1]
Long-term drug release from electrospun fibers for in vivo inflammation prevention in the prevention of peritendinous adhesions.

Acta Biomater. 2013-4-6

[2]
Biomimetic sheath membrane via electrospinning for antiadhesion of repaired tendon.

Biomacromolecules. 2012-10-17

[3]
Prevention of peritendinous adhesions with electrospun ibuprofen-loaded poly(L-lactic acid)-polyethylene glycol fibrous membranes.

Tissue Eng Part A. 2012-11-2

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Colloids Surf B Biointerfaces. 2010-8-3

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BMC Cell Biol. 2009-9-17

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Toxicol Lett. 2009-10-28

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Acta Biomater. 2009-9

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The apoptotic effect of nanosilver is mediated by a ROS- and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells.

Toxicol Lett. 2008-7-10

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Tendon: biology, biomechanics, repair, growth factors, and evolving treatment options.

J Hand Surg Am. 2008-1

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