转移相关结肠癌-1是宫颈癌的一种新型预后标志物。
Metastasis-associated colon cancer-1 is a novel prognostic marker for cervical cancer.
作者信息
Guo Lan, Lu Wanggui, Zhang Xuan, Luo Dixian, Zhang Hongwen
机构信息
Department of Gynaecology and Obstetrics, The First People's Hospital of Chenzhou City Chenzhou, HN 423000, China.
Department of Gynaecology and Obstetrics, The Second Xiangya Hospital Central South University Changsha, HN 410011, China.
出版信息
Int J Clin Exp Pathol. 2014 Jun 15;7(7):4150-5. eCollection 2014.
AIMS
To investigate metastasis associated in colon cancer 1 (MACC1) expression in cervical cancer.
METHODS
One hundred and four paraffin-embedded cervical cancer specimens were immunohistochemically analyzed for MACC1 expression. The expression of MACC1 in 8 pairs of cervical cancer and adjacent normal cervical tissues were detected by Real-time PCR.
RESULTS
MACC1 expression was upregulated in cervical cancer tissues compared with adjacent normal cervical tissues. Patients with higher MACC1 expression had shorter overall survival time, whereas those with lower ASAP1 expression survived longer (P = 0.029). Moreover, high expression of MACC1 was correlated with FIGO stage (P = 0.039) and lymph nodes metastasis (P = 0.003) of this disease. Multivariate analysis revealed that MACC1 was an independent prognostic factor (P = 0.043) for the overall survival of cervical cancer patients.
CONCLUSION
Our study suggests that MACC1 may contribute to tumor development and progression in cervical cancer, and that MACC1 could be a useful marker for the prognosis of cervical cancer.
目的
研究结肠癌转移相关蛋白1（MACC1）在宫颈癌中的表达情况。
方法
采用免疫组织化学方法分析104例石蜡包埋的宫颈癌标本中MACC1的表达。应用实时荧光定量PCR检测8对宫颈癌组织及癌旁正常宫颈组织中MACC1的表达。
结果
与癌旁正常宫颈组织相比，宫颈癌组织中MACC1表达上调。MACC1高表达患者的总生存时间较短，而ASAP1低表达患者生存时间较长（P = 0.029）。此外，MACC1高表达与该疾病的国际妇产科联盟（FIGO）分期（P = 0.039）及淋巴结转移（P = 0.003）相关。多因素分析显示，MACC1是宫颈癌患者总生存的独立预后因素（P = 0.043）。
结论
我们的研究表明，MACC1可能促进宫颈癌的肿瘤发生和进展，并且MACC1可能是宫颈癌预后的一个有用标志物。
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