Topcu Hasan Onur, Guzel Ali Irfan, Ozer Irfan, Kokanali Mahmut Kuntay, Gokturk Umut, Muftuoglu Kamil Hakan, Doganay Melike
Obstetrics and Gynecology, Medicine, Dr Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey E-mail :
Asian Pac J Cancer Prev. 2014;15(15):6239-41. doi: 10.7314/apjcp.2014.15.15.6239.
To compare the diagnostic accuracy of the neutrophil/lymphocyte ratio (NLR) with the platelet/lymphocyte ratio (PLR) in predicting malignancy of pelvic masses which are pre-operatively malignant suspicious.
In this retrospective study we evaluated the clinical features of patients with ovarian masses which had pre-operatively been considered suspicious for malignancy. The patients whose intraoperative frozen sections were malign were classified as the study group, while those who had benign masses were the control group. Data recorded were age of the patient, diameter of the mass, pre-operative serum Ca 125 levels, platelet count, neutrophil/lymphocyte ratio and platelet/lymphocyte ratio.
There was statistically significantly difference between the groups in terms of age, diameter of the mass, serum Ca 125 levels, platelet number and platelet/lymphocyte ratio. Mean neutrophil/lymphocyte ratios showed no difference between the groups. ROC curve analysis showed that age, serum Ca 125 levels, platelet number and PLR were discriminative markers in predicting malignancy in adnexal masses.
According to the current study, serum Ca 125 levels, pre-operative platelet number and PLR may be good prognostic factors, while NLR is an ineffective marker in predicting the malignant characteristics of a pelvic mass.
比较中性粒细胞/淋巴细胞比值（NLR）与血小板/淋巴细胞比值（PLR）在预测术前怀疑为恶性的盆腔肿块恶性程度方面的诊断准确性。
在这项回顾性研究中，我们评估了术前被认为怀疑为恶性的卵巢肿块患者的临床特征。术中冰冻切片为恶性的患者被分类为研究组，而肿块为良性的患者为对照组。记录的数据包括患者年龄、肿块直径、术前血清Ca 125水平、血小板计数、中性粒细胞/淋巴细胞比值和血小板/淋巴细胞比值。
两组在年龄、肿块直径、血清Ca 125水平、血小板数量和血小板/淋巴细胞比值方面存在统计学显著差异。两组的平均中性粒细胞/淋巴细胞比值无差异。ROC曲线分析表明，年龄、血清Ca 125水平、血小板数量和PLR是预测附件肿块恶性程度的鉴别标志物。
根据目前的研究，血清Ca 125水平、术前血小板数量和PLR可能是良好的预后因素，而NLR在预测盆腔肿块的恶性特征方面是一个无效的标志物。
