Wang Xianfeng, Ding Bin, Li Bingyun
Department of Orthopaedics, School of Medicine, West Virginia University, Morgantown, WV 26506, United States ; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China.
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China.
Mater Today (Kidlington). 2013 Jun 1;16(6):229-241. doi: 10.1016/j.mattod.2013.06.005.
Biomimetic nanofibrous scaffolds mimicking important features of the native extracellular matrix provide a promising strategy to restore functions or achieve favorable responses for tissue regeneration. This review provides a brief overview of current state-of-the-art research designing and using biomimetic electrospun nanofibers as scaffolds for tissue engineering. It begins with a brief introduction of electrospinning and nanofibers, with a focus on issues related to the biomimetic design aspects. The review next focuses on several typical biomimetic nanofibrous structures (e.g. aligned, aligned to random, spiral, tubular, and sheath membrane) that have great potential for tissue engineering scaffolds, and describes their fabrication, advantages, and applications in tissue engineering. The review concludes with perspectives on challenges and future directions for design, fabrication, and utilization of scaffolds based on electrospun nanofibers.
模仿天然细胞外基质重要特征的仿生纳米纤维支架为恢复组织功能或实现有利于组织再生的反应提供了一种很有前景的策略。本综述简要概述了当前设计和使用仿生电纺纳米纤维作为组织工程支架的前沿研究。首先简要介绍了静电纺丝和纳米纤维，重点关注与仿生设计方面相关的问题。接下来，综述聚焦于几种对组织工程支架具有巨大潜力的典型仿生纳米纤维结构（如排列的、从排列到随机的、螺旋的、管状的和鞘膜），并描述了它们的制造方法、优点及其在组织工程中的应用。综述最后展望了基于电纺纳米纤维的支架在设计、制造和应用方面所面临的挑战及未来发展方向。
