Rosenberg Stacy L, Miller Gregory E, Brehm John M, Celedón Juan C
Division of Pediatric Pulmonary Medicine, Allergy and Immunology, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, Pa.
Department of Psychology, Northwestern University, Evanston, Ill.
J Allergy Clin Immunol. 2014 Nov;134(5):1009-15. doi: 10.1016/j.jaci.2014.07.005. Epub 2014 Aug 13.
In the United States the economically disadvantaged and some ethnic minorities are often exposed to chronic psychosocial stressors and disproportionately affected by asthma. Current evidence suggests a causal association between chronic psychosocial stress and asthma or asthma morbidity. Recent findings suggest potential mechanisms underlying this association, including changes in the methylation and expression of genes that regulate behavioral, autonomic, neuroendocrine, and immunologic responses to stress. There is also evidence suggesting the existence of susceptibility genes that predispose chronically stressed youth to both post-traumatic stress disorder and asthma. In this review we critically examine published evidence and suggest future directions for research in this field.
在美国，经济上处于不利地位的人群和一些少数族裔经常面临慢性心理社会压力源，且受哮喘影响的比例过高。目前的证据表明慢性心理社会压力与哮喘或哮喘发病率之间存在因果关联。最近的研究结果提示了这种关联背后的潜在机制，包括调节对应激的行为、自主神经、神经内分泌和免疫反应的基因的甲基化和表达变化。也有证据表明存在易感基因，使长期处于压力下的青少年易患创伤后应激障碍和哮喘。在本综述中，我们批判性地审视已发表的证据，并提出该领域未来的研究方向。
